Day: November 24, 2023

On the eve of international climate talks, U.N. Secretary-General Antonio Guterres visited globally important Antarctica, where ice that’s been frozen for millions of years is melting because of human-caused climate change, to send the message that “we absolutely need to act immediately.” 

“What happens in Antarctica doesn’t stay in Antarctica,” Guterres said. In addition to reflecting lots of sunlight away from the Earth, Antarctica regulates the planet’s climate because its ice and cold waters drive major ocean currents. When massive amounts of ice melt, it raises sea levels and changes things like salinity and the habitats of ocean animals. 

At the annual Conference of the Parties known as COP, nations are supposed to gather to make and strengthen commitments to addressing climate change, but so far these have not been nearly enough to slow the emissions causing the warming. 

Guterres is on a three-day official visit to the southern continent. Chilean President Gabriel Boric joined him for an official visit to Chile’s Eduardo Frei Air Force Base on King George Island. Scientists and members of the Chilean military gathered with Guterres aboard a ship where they viewed glaciers and sea birds, including penguins. 

Guterres described COP28, which begins next week in Dubai, as an opportunity for nations to “decide the phase-out of fossil fuels in an adequate time frame” to prevent the world from warming 1.5 degrees Celsius (2.7 degrees Fahrenheit) above pre-industrial temperatures. Scientists have considered that an important demarcation that could have avoided devastating climate change for millions of people. But such a phase-out has not found its way into the agreements that emerge from these conferences so far, and the influence of fossil fuel companies and countries has been strong. 

Guterres said the COP28 conference also gives nations the chance to commit to more renewable energy projects and improve the energy efficiency of existing electrical grids and technologies. 

Sultan al-Jaber, the head of the Abu Dhabi National Oil Co., is president of this year’s talks, and the U.N. chief said his ties to the sector give him a “bigger responsibility” to encourage the fossil fuel industry to make more clean energy investments. 

“He needs to be able to explain to all those that are responsible in the fossil fuel industry, and especially to the oil and gas industry that is making obscene profits all over the world, that this is the moment to use those profits instead of doubling down on fossil fuels,” Guterres said. 

Pope Francis will also be the first pontiff to attend the U.N. climate conference, and Guterres said he was “very hopeful” that the pope’s presence would convey to political leaders that “it is a moral imperative to put climate action as an absolute priority and to do everything that is necessary to move from the suicidal trajectory that we are having today.”
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The World Health Organization said it has confirmed sexual transmission of mpox in the Democratic Republic of Congo for the first time as the country experiences its biggest outbreak, a worrying development that African scientists warn could make it more difficult to stop the disease.

In a statement issued late Thursday, the U.N. health agency said a resident of Belgium traveled to Congo in March and tested positive for mpox, or monkeypox, shortly afterward. The WHO said the individual “identified himself as a man who has sexual relations with other men” and that he had gone to several underground clubs for gay and bisexual men.

Among his sexual contacts, five later tested positive for mpox, the WHO said.

“This is the first definitive proof of sexual transmission of monkeypox in Africa,” said Oyewale Tomori, a Nigerian virologist who sits on several WHO advisory groups. “The idea that this kind of transmission could not be happening here has now been debunked.”

Mpox has been endemic in parts of central and west Africa for decades, where it mostly jumped into humans from infected rodents and caused limited outbreaks. Last year, epidemics triggered mainly by sex among gay and bisexual men in Europe hit more than 100 countries. The WHO declared the outbreak as a global emergency, and it has caused about 91,000 cases to date.

The WHO noted there were dozens of discrete clubs in Congo where men have sex with other men, including members who travel to other parts of Africa and Europe. The agency described the recent mpox outbreak as unusual and said it highlighted the risk the disease could spread widely among sexual networks.

The WHO added that the mpox outbreak this year in Congo, which has infected more than 12,500 people and killed about 580, also marked the first time the disease has been identified in the capital, Kinshasa, and in the conflict-ridden province of South Kivu. Those figures are roughly double the mpox toll in 2020, making it Congo’s biggest outbreak, the WHO said.

Virologist Tomori said that even those figures were likely an underestimate and had implications for the rest of Africa, given the continent’s often patchy disease surveillance.

“What’s happening in Congo is probably happening in other parts of Africa,” he said. “Sexual transmission of monkeypox is likely established here, but [gay] communities are hiding it because of the draconian [anti-LGBTQ+] laws in several countries.”

He warned that driving people at risk for the virus underground would make the disease harder to curb.

The mpox virus causes fever, chills, rash and lesions on the face or genitals. Most people recover within several weeks without requiring hospitalization.

The WHO said the risk of mpox spreading to other countries in Africa and globally “appears to be significant,” adding that there could be “potentially more severe consequences” than the worldwide epidemic last year.

Tomori lamented that while the mpox outbreaks in Europe and North America prompted mass immunization campaigns among affected populations, no such plans were being proposed for Africa.

“Despite the thousands of cases in Congo, no vaccines have arrived,” he said. Even after mpox epidemics subsided in the West, few shots or treatments were made available for Africa.

“We have been saying for years in Africa that monkeypox is a problem,” he said. “Now that sexual transmission has been confirmed here, this should be a signal to everyone to take it much more seriously.”
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South Africa, Colombia and other countries that lost out in the global race for coronavirus vaccines are taking a more combative approach toward drugmakers and pushing back on policies that deny cheap treatment to millions of people with tuberculosis and HIV.

Experts see it as a shift in how such countries deal with pharmaceutical behemoths and say it could trigger more efforts to make lifesaving medicines more widely available.

In the COVID-19 pandemic, rich countries bought most of the world’s vaccines early, leaving few shots for poor countries and creating a disparity the World Health Organization called “a catastrophic moral failure.”

Now, poorer countries are trying to become more self-reliant “because they’ve realized after COVID they can’t count on anyone else,” said Brook Baker, who studies treatment-access issues at Northeastern University.

One of the targets is a drug, bedaquiline, that is used for treating people with drug-resistant versions of tuberculosis. The pills are especially important for South Africa, where TB killed more than 50,000 people in 2021, making it the country’s leading cause of death.

In recent months, activists have protested efforts by Johnson & Johnson to protect its patent on the drug. In March, TB patients petitioned the Indian government, calling for cheaper generics; the government ultimately agreed Johnson & Johnson’s patent could be broken. Belarus and Ukraine then wrote to the company, also asking it to drop its patents, but with little response.

In July, Johnson & Johnson’s patent on the drug expired in South Africa, but the company had it extended until 2027, enraging activists who accused it of profiteering.

The South African government then began investigating the company’s pricing policies.

It had been paying about 5,400 rand ($282) per treatment course, more than twice as much as poor countries that got the drug via a global effort called the Stop TB partnership.

In September, about a week after South Africa’s probe began, Johnson & Johnson announced that it would drop its patent in more than 130 countries, allowing generic-makers to copy the drug.

“This addresses any misconception that access to our medicines is limited,” the company said.

Christophe Perrin, a tuberculosis expert at Doctors Without Borders, called Johnson & Johnson’s reversal “a big surprise” because aggressive patent protection was typically a “cornerstone” of pharmaceutical companies’ strategy.

Meanwhile, in Colombia, the government declared last month that it would issue a compulsory license for the HIV drug dolutegravir without permission from the drug’s patent-holder, Viiv Health care. The decision came after more than 120 groups asked the Colombian government to expand access to the World Health Organization-recommended drug.

“This is Colombia taking the reins after the extreme inequity of COVID and challenging a major pharmaceutical to ensure affordable AIDS treatment for its people,” said Peter Maybarduk of the Washington advocacy group Public Citizen. He noted that Brazilian activists are pushing their government to make a similar move.

Still, some experts said much more needs to change before poorer countries can produce their own medicines and vaccines.

When the coronavirus pandemic hit, Africa produced fewer than 1% of all vaccines made globally but used more than half of the world’s supply, according to Petro Terblanche, managing director of Afrigen Biologics. The company is part of a WHO-backed effort to produce a COVID vaccine using the same mRNA technology as those made by Pfizer and Moderna.

Terblanche estimated about 14 million people died of AIDS in Africa from the late 1990s into the 2000s, when countries couldn’t get the necessary medicines.

Back then, President Nelson Mandela’s government in South Africa eventually suspended patents to allow wider access to AIDS drugs. That prompted more than 30 drugmakers to take it to court in 1998, in a case dubbed “Mandela vs. Big Pharma.”

Doctors Without Borders described the episode as “a public relations disaster” for the drug companies, which dropped the lawsuit in 2001.

Terblanche said that Africa’s experience during the HIV epidemic has proven instructive.

“It’s not acceptable for a listed company to hold intellectual property that stands in the way of saving lives and, so, we will see more countries fighting back,” she said.

Challenging pharmaceutical companies is just one piece to ensuring Africa has equal access to treatments and vaccines, Terblanche said. More-robust health systems are critical.

“If we can’t get [vaccines and medicines] to the people who need them, they aren’t useful,” she said.

Yet some experts pointed out that South Africa’s own intellectual property laws still haven’t been changed sufficiently and make it too easy for pharmaceutical companies to acquire patents and extend their monopolies.

While many other developing countries allow legal challenges to a patent or a patent extension, South Africa has no clear law that allows it to do that, said Lynette Keneilwe Mabote-Eyde, a health care activist who consults for the nonprofit Treatment Action Group.

The South African department of health didn’t respond to a request for comment regarding drug procurement and patents.

In its annual report on tuberculosis released earlier this month, the World Health Organization said there were more than 10 million people sickened by the disease last year and 1.3 million deaths. After COVID-19, tuberculosis is the world’s deadliest infectious disease, and it is now the top killer of people with HIV.
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