Day: November 18, 2023

Advertisers are fleeing social media platform X over concerns about their ads showing up next to pro-Nazi content and hate speech on the site in general, with billionaire owner Elon Musk inflaming tensions with his own posts endorsing an antisemitic conspiracy theory.

IBM said this week that it stopped advertising on X after a report said its ads were appearing alongside material praising Nazis — a fresh setback as the platform, formerly known as Twitter, tries to win back big brands and their ad dollars, X’s main source of revenue.

The liberal advocacy group Media Matters said in a report Thursday that ads from Apple, Oracle, NBCUniversal’s Bravo network and Comcast also were placed next to antisemitic material on X.

“IBM has zero tolerance for hate speech and discrimination and we have immediately suspended all advertising on X while we investigate this entirely unacceptable situation,” the company said in a statement.

Apple, Oracle, NBCUniversal and Comcast didn’t respond immediately to requests seeking comment on their next steps.

The European Union’s executive branch said separately Friday it is pausing advertising on X and other social media platforms, in part because of a surge in hate speech. Later in the day, Disney, Lionsgate and Paramount Global also said they were suspending or pausing advertising on X.

Musk sparked outcry this week with his own tweets responding to a user who accused Jews of hating white people and professing indifference to antisemitism. “You have said the actual truth,” Musk tweeted in a reply Wednesday.

Musk has faced accusations of tolerating antisemitic messages on the platform since purchasing it last year, and the content on X has gained increased scrutiny since the war between Israel and Hamas began.

“We condemn this abhorrent promotion of antisemitic and racist hate in the strongest terms, which runs against our core values as Americans,” White House spokesperson Andrew Bates said Friday in response to Musk’s tweet.

X CEO Linda Yaccarino said X’s “point of view has always been very clear that discrimination by everyone should STOP across the board.”

“I think that’s something we can and should all agree on,” she tweeted Thursday.

Yaccarino, a former NBCUniversal executive, was hired by Musk to rebuild ties with advertisers who fled after he took over, concerned that his easing of content restrictions was allowing hateful and toxic speech to flourish and that would harm their brands.

“When it comes to this platform — X has also been extremely clear about our efforts to combat antisemitism and discrimination. There’s no place for it anywhere in the world — it’s ugly and wrong. Full stop,” Yaccarino said.

Media Matters and Anti-Defamation League

The accounts that Media Matters found posting antisemitic material will no longer be monetizable and the specific posts will be labeled “sensitive media,” according to a statement from X. Still, Musk decried Media Matters as “an evil organization.”

The head of the Anti-Defamation League also hit back at Musk’s tweets this week, in the latest clash between the prominent Jewish civil-rights organization and the billionaire businessman.

“At a time when antisemitism is exploding in America and surging around the world, it is indisputably dangerous to use one’s influence to validate and promote antisemitic theories,” ADL CEO Jonathan Greenblatt said on X.

Musk also tweeted this week that he was “deeply offended by ADL’s messaging and any other groups who push de facto anti-white racism or anti-Asian racism or racism of any kind.”

The group has previously accused Musk of allowing antisemitism and hate speech to spread on the platform and amplifying the messages of neo-Nazis and white supremacists who want to ban the ADL.

European Commission steps back

The European Commission, meanwhile, said it’s putting all its social media ad efforts on hold because of an “alarming increase in disinformation and hate speech” on platforms in recent weeks.

The commission, the 27-nation EU’s executive arm, said it is advising its services to “refrain from advertising at this stage on social media platforms where such content is present,” adding that the freeze doesn’t affect its official accounts on X.

The EU has taken a tough stance with new rules to clean up social media platforms, and last month it made a formal request to X for information about its handling of hate speech, misinformation and violent terrorist content related to the Israel-Hamas war.

TikTok troubles

X isn’t alone in dealing with problematic content since the conflict.

On Thursday, TikTok removed the hashtag #lettertoamerica after users on the app posted sympathetic videos about Osama bin Laden’s 2002 letter justifying the terrorist attacks against Americans on 9/11 and criticizing U.S. support for Israel. The Guardian news outlet, which published the transcript of the letter that was being shared, took it down and replaced it with a statement that directed readers to a news article from 2002 that it said provided more context.

The videos garnered widespread attention among X users critical of TikTok, which is owned by Beijing-based ByteDance. TikTok said the letter was not a trend on its platform and blamed an X post by journalist Yashar Ali and media coverage for drawing more engagement to the hashtag.

The short-form video app has faced criticism from Republicans and others who say the platform has been failing to protect Jewish users from harassment and pushing pro-Palestinian content to viewers.

TikTok has aggressively pushed back, saying it’s been taking down antisemitic content and doesn’t manipulate its algorithm to take sides. 
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SpaceX’s uncrewed spacecraft Starship, developed to carry astronauts to the moon and beyond, was presumed to have failed in space minutes after lifting off on Saturday in a second test after its first attempt to reach space ended in an explosion.

The two-stage rocket ship blasted off from the Elon Musk-owned company’s Starbase launch site near Boca Chica, Texas, soaring roughly 90 kilometers (55 miles) above ground on a planned 90-minute flight into space.

But the rocket’s Super Heavy first stage booster, though it appeared to achieve a crucial maneuver to separate with its core stage, exploded over the Gulf of Mexico shortly after detaching.

Meanwhile, the core Starship booster carried further toward space, but roughly 10 minutes into the flight a company broadcaster said that SpaceX mission control suddenly lost contact with the vehicle.

“We have lost the data from the second stage. … We think we may have lost the second stage,” SpaceX’s livestream host John Insprucker said.

The launch was the second attempt to fly Starship mounted atop its towering Super Heavy rocket booster, following an April attempt that ended in failure about four minutes after liftoff.

A live SpaceX webcast of Saturday’s launch showed the rocket ship rising from the launch tower into the morning sky as the Super Heavy’s cluster of powerful Raptor engines thundered to life.

The test flight’s principal objective was to get Starship off the ground and into space just shy of Earth’s orbit. Doing so would have marked a key step toward achieving SpaceX’s goal of producing a large, multipurpose spacecraft capable of sending people and cargo back to the moon later this decade for NASA, and ultimately to Mars.

Musk — SpaceX’s founder, chief executive and chief engineer — also sees Starship as eventually replacing the company’s workhorse Falcon 9 rocket as the centerpiece of its launch business, which already takes most of the world’s satellites and other commercial payloads into space.

NASA, SpaceX’s primary customer, has a considerable stake in the success of Starship, which the U.S. space agency is counting on to play a central role in its human spaceflight program, Artemis, successor to the Apollo missions of more than a half century ago that put astronauts on the moon for the first time.

The mission’s objective was to get Starship off the ground in Texas and into space just shy of reaching orbit, then plunge through Earth’s atmosphere for a splashdown off Hawaii’s coast. The launch had been scheduled for Friday but was pushed back by a day for a last-minute swap of flight-control hardware.

During its April 20 test flight, the spacecraft blew itself to bits less than four minutes into a planned 90-minute flight that went awry from the start. SpaceX has acknowledged that some of the Super Heavy’s 33 Raptor engines malfunctioned on ascent, and that the lower-stage booster rocket failed to separate as designed from the upper-stage Starship before the flight was terminated. 
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U.S. President Joe Biden and Chinese President Xi Jinping agreed earlier this week that Beijing will crack down on companies in China that produce precursor chemicals for fentanyl, an agreement that Biden said would “save lives.”

In exchange, the Biden administration agreed to lift sanctions on China’s Physical Evidence Identification Center of the Ministry of Public Security and the National Drug Laboratory. In May 2020, the U.S. Department of Commerce sanctioned the lab for allegedly participating in human rights violations against Uyghurs and other ethnic minorities in Xinjiang.

China, which is the source of most fentanyl precursors used in the U.S., argued that U.S. export controls have “severely affected” China’s inspection and testing of fentanyl-related substances and impaired its “goodwill to help the U.S. in drug control,” according to the spokesperson of the Chinese Embassy in the United States.

Although a cooperative effort to curb the supply of fentanyl brought some results over the years, enthusiasm dampened as tensions grew between China and the U.S. On Aug. 5, 2022 — after then-House Speaker Nancy Pelosi visited Taiwan, a self-governing island Beijing considers its own — China officially announced the suspension of anti-drug cooperation with the U.S.

Here is some background to the Biden-Xi deal.

What is fentanyl?

According to the U.S. Centers for Disease Control and Prevention (CDC), fentanyl is 50 times more potent than heroin and 100 times more potent than morphine. It is a prescription drug in the United States used for treating severe pain.

Illegally manufactured fentanyl “is often added to other drugs because of its extreme potency, which makes drugs cheaper, more powerful, more addictive, and more dangerous,” according to the CDC.

Fentanyl sold on the black market is often mixed with heroin and/or cocaine to increase a user’s sense of euphoria, according to the CDC.

Why does the United States care about the fentanyl issue?

Fentanyl is now the leading cause of death among Americans ages 18 to 49, according to U.S. Department of Justice data.

What does the fentanyl problem in the United States have to do with China?

According to a report by the Congressional Research Service: “Prior to 2019, China was the primary source of U.S.-bound illicit fentanyl, fentanyl-related substances, and production equipment.” It said Chinese traffickers supplied fentanyl and fentanyl-related substances to the U.S. via international mail and express consignment operations.

Xi promised then-U.S. President Donald Trump to tighten regulation of fentanyl and related substances when the two met in 2018 on the sidelines of the G20 Summit in Buenos Aires, Argentina. This was seen as a move taken by China to ease trade disputes.

China then passed new laws that took effect on May 1, 2019, to put all fentanyl-related substances under national control.

In July 2022 testimony, a senior adviser to the Office of National Drug Control Policy stated that as a result, “the direct shipment of fentanyl and fentanyl-related substances from China to the United States went down to almost zero.”

What role does China play?

After China regulated fentanyl-related substances, Mexican transnational criminal organizations became the main operators in the production and distribution of illegal fentanyl in the U.S., according to data from the U.S. Drug Enforcement Administration (DEA).

“The cartels are buying precursor chemicals in the People’s Republic of China (PRC); transporting the precursor chemicals from the PRC to Mexico; using the precursor chemicals to mass produce fentanyl; pressing the fentanyl into fake prescription pills; and using cars, trucks, and other routes to transport the drugs from Mexico into the United States for distribution,” said Anne Milgram, administrator of DEA, at a Senate hearing in February.

Why does the US accuse China of lax cooperation?

Certain precursors used in the production of fentanyl are internationally classified as unscheduled chemicals and legal to produce in China and export. Beijing argues that it cannot restrict the export of precursors that are not illegal.

The U.S. has repeatedly called on China to adopt a “know-your-customer” approach such as identifying and verifying customer identities to ensure that these chemicals are not sold to likely drug traffickers and to alert authorities about such buyers.

However, in an interview with Newsweek in September 2022, Qin Gang, the then-Chinese ambassador to the U.S., said that approach “goes far beyond the obligations of countries under the United Nations Convention on Drug Control.”
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Britain’s medicines regulator has authorized the world’s first gene therapy treatment for sickle cell disease, in a move that could offer relief to thousands of people with the crippling disease in the U.K.

In a statement Thursday, the Medicines and Healthcare Regulatory Agency said it approved Casgevy, the first medicine licensed using the gene editing tool CRISPR, which won its makers a Nobel prize in 2020.

The agency approved the treatment for patients with sickle cell disease and thalassemia who are 12 years old and older. Casgevy is made by Vertex Pharmaceuticals (Europe) Ltd. and CRISPR Therapeutics. To date, bone marrow transplants, extremely arduous procedures that come with very unpleasant side effects, have been the only long-lasting treatment.

“The future of life-changing cures resides in CRISPR based (gene-editing) technology,” said Dr. Helen O’Neill of University College London.

“The use of the word ‘cure’ in relation to sickle cell disease or thalassemia has, up until now, been incompatible,” she said in a statement, calling the MHRA’s approval of gene therapy “a positive moment in history.”

Both sickle cell disease and thalassemia are caused by mistakes in the genes that carry hemoglobin, the protein in red blood cells that carry oxygen. 

In people with sickle cell — which is particularly common in people with African or Caribbean backgrounds — a genetic mutation causes the cells to become crescent-shaped, which can block blood flow and cause excruciating pain, organ damage, stroke and other problems.

In people with thalassemia, the genetic mutation can cause severe anemia. Patients typically require blood transfusions every few weeks, and injections and medicines for their entire life. Thalassemia predominantly affects people of South Asian, Southeast Asian and Middle Eastern heritage.

The new medicine, Casgevy, works by targeting the problematic gene in a patient’s bone marrow stem cells so that the body can make properly functioning hemoglobin.

Patients first receive a course of chemotherapy, before doctors take stem cells from the patient’s bone marrow and use genetic editing techniques in a laboratory to fix the gene. The cells are then infused back into the patient for a permanent treatment. Patients must be hospitalized at least twice — once for the collection of the stem cells and then to receive the altered cells.

“This is so exciting. It’s a new wave of treatments that we can utilize for patients with sickle cell disease,” said Dr. James LaBelle, director of the pediatric stem cell and cellular therapy program at the University of Chicago. He said Britain’s approval suggested the U.S. authorization was likely “imminent.”

Casgevy is currently being reviewed by the U.S. Food and Drug Administration; the agency is expected to make a decision early next month, before considering another sickle cell gene therapy.

LaBelle said officials at the University of Chicago are “already moving forward to build not only the clinical infrastructure but also the reimbursement infrastructure to get these patients this treatment.”

Britain’s regulator said its decision to authorize the gene therapy for sickle cell disease was based on a study done on 29 patients, of whom 28 reported having no severe pain problems for at least one year after being treated. In the study for thalassemia, 39 out of 42 patients who got the therapy did not need a red blood cell transfusion for at least a year afterwards.

Gene therapy treatments can cost millions of dollars and experts have previously raised concerns that they could remain out of reach for the people who would benefit most.

Last year, Britain approved a gene therapy for a fatal genetic disorder that had a list price of £2.8 million ($3.5 million). England’s National Health Service negotiated a significant confidential discount to make it available to eligible patients.

Vertex Pharmaceuticals said it had not yet established a price for the treatment in Britain and was working with health authorities “to secure reimbursement and access for eligible patients as quickly as possible.”

In the U.S., Vertex has not released a potential price for the therapy, but a report by the nonprofit Institute for Clinical and Economic Review said prices up to around $2 million would be cost-effective. By comparison, research earlier this year showed medical expenses for current sickle cell treatments, from birth to age 65, add up to about $1.6 million for women and $1.7 million for men.

Medicines and treatments in Britain must be recommended by a government watchdog before they are made freely available to patients in the national health care system.

Millions of people around the world, including about 100,000 in the U.S., have sickle cell disease. It occurs more often among people from places where malaria is or was common, like Africa and India, and is also more common in certain ethnic groups, such as people of African, Middle Eastern and Indian descent. Scientists believe being a carrier of the sickle cell trait helps protect against severe malaria.
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The U.S. flu season is under way, with at least seven states reporting high levels of illnesses and cases rising in other parts of the country, health officials say.

The Centers for Disease Control and Prevention posted new flu data Friday, showing very high activity last week in Louisiana, and high activity in Alabama, Florida, Georgia, Mississippi, New Mexico and South Carolina. It was also high in the District of Columbia and Puerto Rico, the U.S. territory where health officials declared an influenza epidemic earlier this month.

“We’re off to the races,” said Dr. William Schaffner, a Vanderbilt University infectious diseases expert.

Traditionally, the winter flu season ramps up in December or January. But it took off in October last year, and is making a November entrance this year.

Flu activity was moderate but rising in New York City, Arkansas, California, Maryland, New Jersey, North Carolina, Tennessee and Texas. And while flu activity has been high in Alaska for weeks, the state did not report data last week, so it wasn’t part of the latest count.

Tracking during flu season relies in part on reports of people with flu-like symptoms who go to doctor’s offices or hospitals; many people with the flu are not tested, so their infections aren’t lab-confirmed. COVID-19 and other respiratory viruses can sometimes muddy the picture.

Alicia Budd, who leads the CDC’s flu surveillance team, said several indicators are showing “continued increases” in flu.

There are different kinds of flu viruses, and the version that’s been spreading the most so far this year usually leads to a lesser amount of hospitalizations and deaths in the elderly — the group on whom flu tends to take the largest toll.

So far this fall, the CDC estimates at least 780,000 flu illnesses, at least 8,000 hospitalizations and at least 490 flu-related deaths — including at least one child.

Budd said that it’s not yet clear exactly how effective the current flu vaccines are, but the shots are well-matched to the flu strains that are showing up. In the U.S., about 35% of U.S. adults and 33% of children have been vaccinated against flu, current CDC data indicates. That’s down compared to last year in both categories.

Flu vaccination rates are better than rates for the other two main respiratory viruses — COVID-19 and RSV. About 14% of adults and 5% of children have gotten the currently recommended COVID-19 shot, and about 13.5% of adults 60 and older have gotten one of the RSV shots that became available earlier this year.
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