Day: October 2, 2023

Two scientists who jointly worked on the ground-breaking technology behind some of the most effective COVID-19 vaccines have been awarded the 2023 Nobel Prize for medicine, one of the most prestigious accolades in the field.

Hungarian American scientist Katalin Kariko and her American colleague, Drew Weissman, began working on so-called “mRNA” technology in the early 1990s at the University of Pennsylvania. Their breakthrough was crucial in developing the Moderna and Pfizer-BioNtech coronavirus vaccines, which have proved among the most effective in tackling COVID-19.

Lifesaving vaccines

The Nobel Prize in Medicine Committee in Sweden said the discovery had helped defeat one of the greatest threats to human health in modern times.

“mRNA vaccines, together with other COVID-19 vaccines, have been administered over 13 billion times. Together, they have saved millions of lives, prevented severe COVID-19, reduced the overall disease burden, and enabled societies to open up again,” Nobel committee member Rickard Sandberg told reporters following the announcement Monday.

“mRNA technologies are now being used to develop vaccines against other infections. The technology may also be used for therapeutic protein delivery and cancer treatment in the hope of further improving human health,” Sandberg said.

World Health Organization Director-General Tedros Adhanom Ghebreyesus congratulated the Nobel Prize winners Monday. “Today is a great day for health, a great day for science and a great day for vaccines,” he told reporters in Geneva.

mRNA Technology

mRNA — or messenger RNA — instructs cells to make proteins that match those found on the surface of pathogens, like the coronavirus. The body sees these as invaders and makes antibodies and T-cells to attack them; thus, training it to deal with a real virus in the future.

Kariko and Weissman first met while lining up to use a photocopier machine at the University of Pennsylvania in the early 1990s.

By 2005, the pair had worked out a way to stop the immune system from attacking RNA made in the laboratory, previously seen as a major hurdle against its use.

Kariko said Monday they made a good team.

“I was the RNA person and Drew was [the] immunologist, and we educated each other. And together we learned [from] each other and developed mRNA,” she told The Associated Press.

Future applications

Weissman said the future potential for mRNA was incredible.

“We’ve been thinking for years about everything that we could do with RNA, and now it’s here,” he told AP.

The coronavirus pandemic accelerated the development of mRNA technology, said Paul Hunter, a professor of medicine at Britain’s University of East Anglia.

“Prior to COVID, people knew that work was being done on mRNA vaccines,” he told VOA. “But I don’t think we were ever close to getting real-world use of the technology. Now that it’s been shown to work — to work probably better than many if not most other vaccine types — I think is a big boost to it, and there are a substantial number of potential uses of this technology.

“Then there is the speed of the development of this technology,” he added. “It’s a lot easier now and a lot quicker to develop new vaccines.”

Cancer hope

The chair of the Nobel Committee for Medicine, Gunilla Karlsson-Hedestam, expressed hope that mRNA technology could one day be used to fight cancer.

“Vaccines that are targeted towards specific kinds of tumors, maybe even to specific individuals or personalized cancers. That will become an area that this platform is really ideally suited for, because of the flexibility,” she told Reuters.

Kariko and Weissman share the prize of $1 million and will receive their medals at a ceremony in Stockholm in December.
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A Kenyan parliamentary panel called on the country’s information technology regulator on Monday to shut down the operations of cryptocurrency project Worldcoin within the country until more stringent regulations are put in place.

The government suspended the project in early August following privacy objections over its scanning of users’ irises in exchange for a digital ID to create a new “identity and financial network.”

Worldcoin was rolled out in various countries around the world by Tools for Humanity, a company co-founded by OpenAI CEO Sam Altman. It has also come under scrutiny in Britain, Germany and France.

The project still has a virtual presence in Kenya and can be accessed via the internet, even after the August suspension.

The regulatory Communications Authority of Kenya should “disable the virtual platforms of Tools for Humanity Corp and Tools for Humanity GmbH Germany [Worldcoin] including blacklisting the IP addresses of related websites,” the ad hoc panel of 18 lawmakers said in a report.

It also called for the suspension of the companies’ “physical presence in Kenya until there is a legal framework for regulation of virtual assets and virtual services providers.”

Worldcoin’s press office said it had “not seen anything official announced by the Committee directly.”

The panel’s report will be tabled at the National Assembly for consideration and adoption at a later date.

During the suspension of data collection in August, authorities said the project’s method of obtaining consumer consent in return for a monetary award of just over $50 at the time bordered on inducement.

Registering to use the platform involved long lines of people queuing to get their irises scanned. The parliamentary panel’s investigation found that Worldcoin may have scanned the eyes of minors as there was no age-verification mechanism during the exercise, its report said.

The panel also asked government ministries to develop regulations for crypto assets and firms that provide crypto services and called on the police to investigate Tools for Humanity and take any necessary legal action.
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An endangered Sumatran rhinoceros, the smallest and hairiest of the five extant rhino species, was born in Indonesia last week in a conservation area, the government said Monday. 

Weighing about 27 kilograms (59.52 lbs.), the yet-to-be named female calf, was born Saturday at the Sumatran Rhino Sanctuary (SRS) facility in Way Kambas National Park, Lampung province in the tropical Southeast Asian country. 

Covered in black hair, the newborn stood about 45 minutes after her birth. On the next day, she began to walk around the jungle, the environment ministry said in a statement. 

The mother, 22-year-old Ratu, was in a healthy condition, the ministry said. 

Ratu is a native of Lampung, while her mate, Andalas, aged 23, was born at the Cincinnati Zoo, in the midwestern U.S. state of Ohio, but has since moved to the same park as Ratu. 

The pair previously had Delilah in 2016 and Andatu in 2021. 

“This is a happy news, not only for Indonesia but for the world,” Indonesia’s environment minister, Siti Nurbaya, said in the statement. 

There were just 80 Sumatran rhinos left in the world, based on a 2019 assessment of threatened species by the Indonesian government. 

The mammal, also known by the scientific name, Dicerorhinus sumatrensis, is the only Asian rhino with two horns and can grow up to 1.5 meters-tall, weighing between 500 kg to 960 kg (1,102 lbs. to 2,116 lbs.). 
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More than 1,000 people have died from dengue fever in Bangladesh this year, making 2023 the deadliest year due to dengue, since the disease was first detected in the country, according to government figures.

The Directorate General of Health Services said that more than 200,000 dengue cases were recorded this year.

In a recent 24-hour period, nearly 3,000 were admitted to hospitals because of dengue, the Daily Star newspaper said.

The Mayo Clinic says dengue fever is “a mosquito-borne illness that occurs in tropical and subtropical areas of the world. Mild dengue fever causes a high fever and flu-like symptoms. The severe form of dengue fever, also called dengue hemorrhagic fever, can cause serious bleeding, a sudden drop in blood pressure [shock] and death.”

“All our efforts to control the mosquito population have been ineffective,” Mushtaq Hussain, a consultant at Bangladesh’s Institute of Epidemiology, Disease Control and Research, told The Daily Star. He said the extended monsoon season is another contributing factor to the high case load.

Some information for this report came from AFP.
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Two scientists won the Nobel Prize in medicine on Monday for discoveries that enabled the development of mRNA vaccines against COVID-19.

The award was given to Katalin Karikó, a professor at Sagan’s University in Hungary and an adjunct professor at the University of Pennsylvania, and Drew Weissman, who performed his prizewinning research together with Karikó at the University of Pennsylvania.

“Through their groundbreaking findings, which have fundamentally changed our understanding of how mRNA interacts with our immune system, the laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times,” the panel that awarded the prize said.

Thomas Perlmann, secretary of the Nobel Assembly, announced the prize and said both scientists were “overwhelmed” by news of the prize when he contacted them shortly before the announcement.

Gunilla Karlsson Hedestam, part of the panel that chose the winners, said of their work that “in terms of saving lives, especially in the early phase of the pandemic, it was very important.”

The Nobel Prize in physiology or medicine was won last year by Swedish scientist Svante Paabo for discoveries in human evolution that unlocked secrets of Neanderthal DNA which provided key insights into our immune system, including our vulnerability to severe COVID-19.

The award was the second in the family. Paabo’s father, Sune Bergstrom, won the Nobel Prize in medicine in 1982.

Nobel announcements continue with the physics prize on Tuesday, chemistry on Wednesday and literature on Thursday. The Nobel Peace Prize will be announced Friday and the economics award on Oct. 9.

The prizes carry a cash award of 11 million Swedish kronor ($1 million). The money comes from a bequest left by the prize’s creator, Swedish inventor Alfred Nobel, who died in 1896.

The prize money was raised by 1 million kronor this year because of the plunging value of the Swedish currency.

The laureates are invited to receive their awards at ceremonies on Dec. 10, the anniversary of Nobel’s death. The prestigious peace prize is handed out in Oslo, according to his wishes, while the other award ceremony is held in Stockholm.
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