Day: September 11, 2023

British scientist Ian Wilmut, whose research was central to the creation of the cloned animal, Dolly the Sheep, has died at the age of 79, the University of Edinburgh said on Monday.  

His death on Sunday, years after being diagnosed with Parkinson’s disease, was announced by the University of Edinburgh, where he worked. 

Wilmut, along with Keith Campbell from the Roslin animal sciences research institute in Scotland, generated news headlines and heated ethical debates in 1996 when they created Dolly, the first mammal to be cloned from an adult cell. 

“He led efforts to develop cloning, or nuclear transfer, techniques that could be used to make genetically modified sheep. It was these efforts which led to the births of Megan and Morag in 1995 and Dolly in 1996,” the university said in a statement. 

Dolly, named after country singer Dolly Parton, was the first mammal to be cloned from an adult cell, using a process called somatic cell nuclear transfer (SCNT). 

This involved taking a sheep egg, removing its DNA and replacing it with DNA from a frozen udder cell of a sheep that died years before. The egg was then zapped with electricity to make it grow like a fertilized embryo. No sperm were involved. 

Dolly’s creation triggered fears of human reproductive cloning, or producing genetic copies of living or dead people, but mainstream scientists have ruled this out as far too dangerous. 

Wilmut, who was born near Stratford-upon-Avon, attended the University of Nottingham, initially to study agriculture, before switching to animal science.  

He moved to the University of Edinburgh in 2005, received a knighthood in 2008 and retired from the university in 2012. 
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A “cybersecurity issue” led to the shutdown of some casino and hotel computer systems at MGM Resorts International properties across the U.S., a company official reported Monday. 

The incident began Sunday and the extent of its effect on reservation systems and casino floors in Las Vegas and states including Maryland, Massachusetts, Michigan, Mississippi, New Jersey, New York and Ohio was not immediately known, company spokesman Brian Ahern said. 

“MGM Resorts recently identified a cybersecurity issue affecting some of the company’s systems,” the company said in a statement that pointed to an investigation involving external cybersecurity experts and notifications to law enforcement agencies. 

The nature of the issue was not described, but the statement said efforts to protect data included “shutting down certain systems.” It said the investigation was continuing. 

A post on the company website said the site was down. It listed telephone numbers to reach the reservation system and properties. 

A post on the company’s BetMGM website in Nevada acknowledged that some customers were unable to log on. 

The company has tens of thousands of hotel rooms in Las Vegas at properties including the MGM Grand, Bellagio, Cosmopolitan, Aria, New York-New York, Park MGM, Excalibur, Luxor, Mandalay Bay and Delano. 

It also operates properties in China and Macau. 
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The U.S. approved updated COVID-19 vaccines Monday, hoping to rev up protection against the latest coronavirus strains and blunt any surge this fall and winter.

The Food and Drug Administration decision opens the newest shots from Moderna and Pfizer and its partner BioNTech to most Americans even if they’ve never had a coronavirus vaccination. It’s part of a shift to treat fall updates of the COVID-19 vaccine much like getting a yearly flu shot.

There’s still another step: The Centers for Disease Control and Prevention must sign off. A CDC advisory panel is set to issue recommendations Tuesday on who most needs the updated shots. Vaccinations could begin later this week, and both the COVID-19 and flu shot can be given at the same visit.

COVID-19 hospitalizations have been rising since late summer although – thanks to some lasting immunity from prior vaccinations and infections – not nearly as much as this time last year.

But protection wanes over time and the coronavirus continually churns out new variants that can dodge prior immunity. It’s been a year since the last time the vaccines were tweaked.

Just like earlier vaccinations, the fall round is cleared for adults and children as young as age 6 months. FDA said starting at age 5, most people can get a single dose even if they’ve never had a prior COVID-19 shot.

Younger children might need additional doses depending on their history of COVID-19 infections and vaccinations.

The newest shots target an omicron variant named XBB.1.5. That specific strain is no longer dominant but it’s close enough to coronavirus strains causing most COVID-19 illnesses today that FDA determined it would offer good cross-protection.

These newest shots replace combination vaccines that mixed protection against the original coronavirus strain and even older omicron variants.

Like earlier versions, they’re expected to be most protective against severe illness, hospitalization and death, rather than mild infection.
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DuckDuckGo, which has long complained that Google’s tactics have made it too tough to get people to use their search engine on a mobile phone, will be one of many rivals to the online search giant eyeing a once-in-a-generation antitrust trial set to begin Tuesday.

The United States will argue Google didn’t play by the rules in its efforts to dominate online search in a trial seen as a battle for the soul of the Internet.

The U.S. Justice Department is expected to detail how Google paid billions of dollars annually to device makers like Apple Inc. AAPL.O, wireless companies like AT&T T.N and browser makers like Mozilla to keep Google’s search engine atop the leader board.

DuckDuckGo has also complained, for example, that removing Google as the default search engine on a device and replacing it with DuckDuckGo takes too many steps, helping keep them to a measly 2.3% market share.  

DuckDuckGo, MicrosoftMSFT.O and Yahoo are among a long list of Google competitors who will be watching the trial closely.

“Google makes it unduly difficult to use DuckDuckGo by default. We’re glad this issue is finally going to have its day in court,” said DuckDuckGo spokesman Kamyl Bazbaz who said that Google had a “stranglehold on major distribution points for more than a decade.” 

Google has denied wrongdoing and is prepared to vigorously defend itself.

The legal fight has huge implications for Big Tech, which has been accused of buying or strangling small competitors but has insulated itself against many accusations of breaking antitrust law because the services the companies provide to users are free, as in the case of Alphabet’s Google GOOGL.O and Facebook META.O, or low price, as in the case of Amazon.com AMZN.O.

“It would be difficult to overstate the importance of this case, particularly for monopolies and companies with significant market share,” antitrust lawyer Luke Hasskamp told Reuters.

“This will be a major case, particularly for the major tech companies of the world (Google, Apple, Twitter, and others), which have grown to have an outsized role in nearly all our lives,” he added.

Previous antitrust trials of similar importance include Microsoft, filed in 1998, and AT&T, filed in 1974. The AT&T breakup in 1982 is credited with paving the way for the modern cell phone industry while the fight with Microsoft is credited with opening space for Google and others on the internet.

Congress tried to rein in Big Tech last year but largely missed. It considered bills to check the market power of the companies, like legislation to prevent them from preferencing their own products, but failed to pass the most aggressive of them.

Big Tech’s rivals now pin their hope on Judge Amit Mehta, who was nominated by former President Barack Obama to the U.S. District Court for the District of Columbia.

The lawsuit that goes to trial was brought by former President Donald Trump’s Justice Department. In a rare show of bipartisan agreement, President Joe Biden’s Justice Department has pressed on with the lawsuit and filed a second one against Google in January focused on advertising technology.

Judge Mehta will decide if Google has broken antitrust law in this first trial, and, if so, what should be done. The government has asked the judge to order Google to stop any illegal activity but also urged “structural relief as needed,” raising the possibility that the tech giant could be ordered broken up.

The government’s strongest arguments are those against Google’s revenue sharing agreements with Android makers, which requires Google to be the only search on the smartphone in exchange for a percentage of search advertising revenue, said Daniel McCuaig, a partner at Cohen Milstein who was formerly with the U.S. Justice Department’s Antitrust Division.
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