Month: June 2023

New advances in the fight against a range of cancers have been revealed at the annual meeting of the American Society of Clinical Oncology (ASCO), which wraps up in Chicago on Tuesday.

Here are some of the announcements that have most excited experts.

Lung cancer

One of the trial results that caused a stir in Chicago has raised hopes for a new weapon against lung cancer, the deadliest of all cancers.

The treatment osimertinib was shown to halve the risk of death from a certain type of lung cancer when taken daily after surgery to remove the tumor.

Developed by the pharmaceutical group AstraZeneca, the daily pill targets patients with non-small cell cancer — by far the most common type — as well as a mutation of their epidermal growth factor receptor, or EGFR.

Iris Pauporte, head of research at France’s League Against Cancer, told AFP the advance was a “big ray of hope” for this type of cancer, for which progress has been slow.

Muriel Dahan, head of research at Unicancer, said that if the results are confirmed, it “should change” common practice in treating this kind of lung cancer.

Systematic testing for the EGFR mutation would also become necessary for lung cancer patients, she added.

Brain cancer

Another treatment, called vorasidenib, was found to significantly prolong the progression-free survival of patients with brain tumor glioma, according to clinical trial results.

The daily pill, developed by French pharma firm Servier, aims to block an enzyme responsible for the progression of some brain cancers, which have been particularly difficult to treat.

Patrick Therasse, Servier’s vice-president of oncology research, told AFP that there “have been few therapeutic advances for brain tumors over the last 20 years.”

“Thanks to our targeted treatment, patients avoided cancer progression for 27.7 months, compared to 11.1 months” for those taking a placebo, he added.

Fabrice Andre, head of research at France’s Gustave Roussy cancer center, said “precision medicine opens a door for a disease for which there was nothing until now.”

“It means that science can unblock situations that were catastrophic,” he told AFP.

Unicancer’s Dahan said it was important to “remain cautious” but added that “this could become the new therapeutic standard — depending on further trials.”

Breast cancer

Preliminary trial results also released in Chicago indicated the drug ribociclib reduced the risk of breast cancer recurring by 25 percent for a large group of early-stage survivors.

The drug, developed by Swiss pharmaceutical maker Novartis, is already widely approved around the world. It was tested in combination with hormonal therapy.

ASCO expert Rita Nanda said it was a “very important and practice-changing clinical trial.”

Cervical cancer

There was also good news for patients with early-stage cervical cancer with a low risk of progression.

There was no greater risk of the cancer returning for patients who get a simple hysterectomy, in which the uterus and cervix are removed, than a radical hysterectomy, in which the uppermost part of the vagina is also removed, according to phase three trials.

League Against Cancer’s Pauporte said this was “good news,” adding that “it shows that it’s not just progress involving drugs that was important.”

Ovarian cancer

A trial also presented at ASCO showed that taking the antibody treatment mirvetuximab soravtansine significantly improved the survival rate of patients with ovarian cancer, a particularly deadly form of cancer.

ASCO expert Merry Jennifer Markham said the treatment “demonstrates progress and offers hope for these patients.”

Rectal cancer

Study results released in Chicago indicated that patients with locally advanced rectal cancer could receive chemotherapy without getting radiation therapy before undergoing surgery.

This would spare patients from the brutal side effects of radiation.

Vaccines

Vaccines that treat existing cancer have long been a goal of the medical community.

Preliminary studies announced at the ASCO meeting involved vaccines targeting lung cancer, head and neck cancers, brain tumor glioblastoma and the cancer-causing HPV virus.

Christophe Le Tourneau, an oncologist at France’s Curie Institute which presented a study about a vaccine for a certain form of HPV, said there has been “significant technological progress” in the area recently.

“Therapeutic vaccines, we talk about them more and more, and there are more and more trials in progress,” he said.
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The U.S. Department of Homeland Security is looking at how artificial intelligence can be used to help identify goods made with child or forced labor and prevent those goods from entering the country. VOA’s Julie Taboh has more. VOA footage by Adam Greenbaum.
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Top Chinese officials told Elon Musk about plans to launch new regulations on artificial intelligence on his recent trip to the Asian giant, the tech billionaire said Monday, in his first comments on the two-day visit.

The Twitter owner and Tesla CEO — one of the world’s richest men — held meetings with senior officials in Beijing and employees in Shanghai last week.

“Something that is worth noting is that on my recent trip to China, with the senior leadership there, we had, I think, some very productive discussions on artificial intelligence risks, and the need for some oversight or regulation,” Musk said. “And my understanding from those conversations is that China will be initiating AI regulation in China.”

Praised China

Musk, whose extensive interests in China have long raised eyebrows in Washington, spoke about the exchange in a livestreamed Twitter discussion with Democratic presidential hopeful and vaccine conspiracy theorist Robert Kennedy Jr., the nephew of the late U.S. President John F. Kennedy.

Musk did not tweet while in China and Tesla has not released readouts of Musk’s meeting with officials.

But official Chinese channels said he lavished praise on the country, including for its “vitality and promise,” and expressed “full confidence in the China market.”

Several Chinese companies have been rushing to develop AI services that can mimic human speech since San Francisco-based OpenAI launched ChatGPT in November.

But rapid advancements have stoked global alarm over the technology’s potential for disinformation and misuse.

Musk didn’t elaborate on his discussions in China but was likely referring to a sweeping draft law requiring new AI products to undergo a security assessment before release and a process ensuring that they reflect “core socialist values.”

The “Administrative Measures for Generative Artificial Intelligence Services” edict bans content promoting “terrorist or extremist propaganda,” “ethnic hatred” or “other content that may disrupt economic and social order.”

Under Beijing’s highly centralized political system, the measures are almost certain to become law.

Describes meetings as ‘promising’

Musk has caused controversy by suggesting the self-ruled island of Taiwan should become part of China — a stance that was welcomed by Chinese officials but which deeply angered Taipei.

The 51-year-old South African native described his meetings in China as “very promising.”

“I pointed out that if there is a digital super intelligence that is overwhelmingly powerful, developed in China, it is actually a risk to the sovereignty of the Chinese government,” he said. “And I think they took that concern to heart.”
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Global leaders in the battle against global warming convened in Bonn, Germany, on Monday for the start of the final phase of a two-year long assessment of the progress being made to limit rising temperatures.

The annual Bonn Climate Change Conference is part of the “global stocktake” — a process by which countries around the world assess how much progress has been made toward compliance with the 2015 Paris Agreement, a worldwide effort to prevent global temperatures from exceeding 1.5 degrees Celsius above the pre-industrial era average.

“The global stocktake is an ambition exercise. It’s an accountability exercise. It’s an acceleration exercise,” U.N. Climate Change Executive Secretary Simon Stiell said in a statement. “It’s an exercise that is intended to make sure every Party is holding up their end of the bargain, knows where they need to go next and how rapidly they need to move to fulfill the goals of the Paris Agreement.”

However, Stiell warned that the findings will only be meaningful if they are paired with action.

“The global stocktake will end up being just another report unless governments and those that they represent can look at it and ultimately understand what it means for them and what they can and must do next. It’s the same for businesses, communities and other key stakeholders,” he said.

The stocktake will conclude in November, when the annual U.N. Climate Change Conference (COP28) is held in Dubai, United Arab Emirates.

Stocktake process

The global stocktake is a two-year process that happens once every five years, as dictated by the Paris Agreement. It has three parts: an information collection and preparation phase, a technical assessment and a consideration of the process’s outputs.

The stocktake began in 2021, with countries, NGOs, experts and other stakeholders gathering information about efforts currently underway to slow global warming. This includes efforts by individual countries to meet the emission-reduction goals they have agreed to at previous COP gatherings — known as nationally determined contributions (NDCs) — as well as challenges and barriers to meeting those goals, and data about new mitigation techniques.

At last year’s Bonn Climate Conference, technical experts began to assess the findings, a process meant to be finalized over this year’s 10-day gathering.

The consideration of the findings will begin immediately following the conference and will be translated into recommendations for further action meant to be finalized in Dubai later this year.

No mystery

While the final details of the global stocktake will not be published until later this year, there is little mystery about what the process is likely to uncover. An interim report published in March found that progress has been “significant yet inadequate” in terms of reaching the goals set out in the Paris Agreement.

“While the remarkable speed with which the Paris Agreement entered into force in 2016 demonstrates a broad commitment, and Parties are making progress in implementation, we as a global community are not on track to meet its long-term goals,” the report found.

Still, experts said that there are reasons for optimism.

“The big value out of the global stocktake is that it’s also meant to be telling us not only where we are and where we need to be, but how to get there. What we’re hearing through the process so far is that there are solutions across all sectors and all [greenhouse] gases,” Maggie Ferrato, a manager for global climate cooperation at the Environmental Defense Fund, told VOA.

“And really the challenge is to kind of distill really clear signals from the wealth of information that’s out there on the highest impact opportunities that should be incorporated into Nationally Determined Contributions in the next round.”

More upbeat assessment

The Bonn Conference comes just a few weeks after a pair of reports from U.N.-affiliated research organizations painted grim pictures of the planet’s climate future.

In March, the Intergovernmental Panel on Climate Change warned that the planet is getting close to being unable to avoid a temperature increase of more than 1.5 degrees Celsius and predicted that more negative consequences of global climate change will soon become apparent. It said that the changes will frequently harm poor and vulnerable populations across the globe, many of which have contributed little to global warming.

Last month, the World Meteorological Organization issued a report that found a two-thirds chance the world will experience at least one year of temperatures averaging more than 1.5 degrees over the pre-industrial average within the next five years.

Michael Mehling, deputy director of the Center for Energy and Environmental Policy Research at the Massachusetts Institute of Technology, told VOA that organizers of the Bonn Conference and of the COP process in general seem to realize unremitting gloom about the climate future may be doing more harm than good.

“I think there’s certainly a realization that just always saying, ‘We’re far behind. Everything looks terrible,’ is losing some impact,” he said.

Mehling said that he anticipates a report that recognizes that progress has been made and that achieving a less ambitious goal of keeping warming below 2 degrees — a level that scientists warn could be catastrophic — is achievable.

“I would probably anticipate some sort of a split message that suggests that we have to continue holding the line and staying [focused] on 2 degrees, but we can achieve that,” he said. “But it doesn’t look good for 1.5, unless we dramatically change what we’re doing. That’s what I expect to be the headline message.”
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The European Union is pushing online platforms like Google and Meta to step up the fight against false information by adding labels to text, photos and other content generated by artificial intelligence, a top official said Monday.

EU Commission Vice President Vera Jourova said the ability of a new generation of AI chatbots to create complex content and visuals in seconds raises “fresh challenges for the fight against disinformation.”

Jourova said she asked Google, Meta, Microsoft, TikTok and other tech companies that have signed up to the 27-nation bloc’s voluntary agreement on combating disinformation to dedicate efforts to tackling the AI problem.

Online platforms that have integrated generative AI into their services, such as Microsoft’s Bing search engine and Google’s Bard chatbot, should build safeguards to prevent “malicious actors” from generating disinformation, Jourova said at a briefing in Brussels.

Companies offering services that have the potential to spread AI-generated disinformation should roll out technology to “recognize such content and clearly label this to users,” she said.

Jourova said EU regulations are aimed at protecting free speech, but when it comes to AI, “I don’t see any right for the machines to have the freedom of speech.”

The swift rise of generative AI technology, which has the capability to produce human-like text, images and video, has amazed many and alarmed others with its potential to transform many aspects of daily life. Europe has taken a lead role in the global movement to regulate artificial intelligence with its AI Act, but the legislation still needs final approval and won’t take effect for several years.

Officials in the EU, which is bringing in a separate set of rules this year to safeguard people from harmful online content, are worried that they need to act faster to keep up with the rapid development of generative artificial intelligence.

The voluntary commitments in the disinformation code will soon become legal obligations under the EU’s Digital Services Act, which will force the biggest tech companies by the end of August to better police their platforms to protect users from hate speech, disinformation and other harmful material.

Jourova said, however, that those companies should start labeling AI-generated content immediately.

Most of those digital giants are already signed up to the EU code, which requires companies to measure their work on combating disinformation and issue regular reports on their progress.

Twitter dropped out last month in what appeared to be the latest move by Elon Musk to loosen restrictions at the social media company after he bought it last year.

The exit drew a stern rebuke, with Jourova calling it a mistake.

“Twitter has chosen the hard way. They chose confrontation,” she said. “Make no mistake, by leaving the code, Twitter has attracted a lot of attention and its actions and compliance with EU law will be scrutinized vigorously and urgently.”
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A pill has been shown to halve the risk of death from a certain type of lung cancer when taken daily after surgery to remove the tumor, according to clinical trial results presented on Sunday.

The results were unveiled in Chicago at the largest annual conference of cancer specialists, hosted by the American Society for Clinical Oncology.

Lung cancer is the form of the disease that causes the most deaths, with approximately 1.8 million fatalities every year worldwide.

The treatment developed by the pharmaceutical group AstraZeneca is called osimertinib and is marketed under the name Tagrisso. It targets a particular type of lung cancer in patients suffering from so-called non-small cell cancer, the most common type, and showing a particular type of mutation.

These mutations, on what is called the epidermal growth factor receptor, or EGFR, affect 10% to 25% of lung cancer patients in the United States and Europe, and 30 to 40% in Asia.

The clinical trial included some 680 participants at an early stage of the disease (stages 1b to 3a), in more than 20 countries. They had to have been operated on first to remove the tumor, then half of the patients took the treatment daily, and the other a placebo.

The result showed that taking the tablet resulted in a 51% reduction in the risk of death for treated patients, compared to placebo.

After five years, 88% of patients who took the treatment were still alive, compared to 78% of patients who took the placebo.

These data are “impressive,” said Roy Herbst of Yale University, who presented them in Chicago. The drug helps “prevent the cancer from spreading to the brain, to the liver, to the bones,” he added at a press conference.

About a third of cases of non-small cell cancers can be operated on when detected, he said.

“It is hard for me to convey, I think, how important this finding is,” said Nathan Pennell of the Cleveland Clinic Foundation at the press conference.

“We started entering the personalized therapy era for early-stage patients,” said Pennell, who did not take part in the trials, and noted that “we should firmly close the door on one-size-fits-all treatment for people with non-small cell lung cancer.”

Osimertinib is already authorized in dozens of countries for various indications, and has already been given to some 700,000 people, according to a press release from AstraZeneca.

Its approval in the United States for early stages in 2020 was based on previous data that showed an improvement in patient disease-free survival, that is, the time a patient lives without a recurrence of cancer.

But not all doctors have adopted the treatment, and many were waiting for the data on overall survival that was presented on Sunday, said Herbst.

He stressed the need to screen patients to find out if they have the EGFR mutation. Otherwise, he said, “we cannot use this new treatment.”

Osimertinib, which targets the receptor, causes side effects that include severe fatigue, skin rashes or diarrhea.
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In collaboration with the Ukrainian government, the U.S. Agency for International Development, or USAID, has created an app that connects Ukrainians with their government so they can access public services — and use of the app’s code has expanded to different countries. Iryna Matviichuk has the story, narrated by Anna Rice.
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Tour de France organizers have set up an anti-COVID protocol for this year’s race, with riders and team staff banned from signing autographs and eating out of their hotels, a source with direct knowledge of the matter told Reuters Saturday. 

Riders and staff members were allowed out of their hotels last year. Access to the paddock at the start of the stages was open to reporters until midway through the race, when organizers decided to close it to “fight against the propagation of COVID-19.” 

Access to the paddock will be allowed when the Tour starts in Bilbao, Spain, on June 29, with everyone required to wear a mask. 

“For all the team members: Respect a confinement – Limit the interactions outside the race bubble. No eating out. Respect social distancing at the hotel,” the chart, seen by Reuters, said. 

“Do not get too close to the spectators – Social distancing, no selfies, no autograph.” 

On Friday, France reported 3,204 COVID-19 cases in the country. At this time last year, there were about 25,000 reported daily cases in France. 

Giro d’Italia organizers last month set up an anti-COVID protocol near the halfway point of the race after overall leader Remco Evenepoel pulled out after testing positive for coronavirus. 
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The latest threat to the life of Txai Surui is still fresh in her mind. Protesting deforestation in the Amazon with other Indigenous people last week, she found herself held at gunpoint.

“They got out guns and ambushed two days ago,” Surui said. The Indigenous campaigner recalled the confrontation with gunmen in a telephone interview from Brazil with VOA.

“I am 26 and my parents have been getting death threats since before I was born. We are threatened all the time,” Surui said.

Her testimony speaks of the dangers faced by Indigenous protesters and the journalists who report their stories from gunmen hired by illegal loggers or fishermen.

On June 5, 2022, Dom Phillips, a British journalist who wrote for The Guardian and The Washington Post, and Brazilian Indigenous expert Bruno Pereira, went missing.

They had been on a four-day reporting trip looking at the situation for communities in the Javari region of the Amazon and were working on a book together.

Ten days after they went missing, their bodies were found. 

 In May 2023, Brazilian federal police brought criminal charges against the former head of Brazil’s Indigenous protection agency for alleged acts of omission they believe indirectly paved the way for the killings.

Marcelo Xavier, a former police chief and head of the protection agency that covered the region where the killings took place, has not commented on the accusations.

Three fishermen are being held in high-security prisons for their alleged involvement in the killings while a judge prepares to rule on whether they will face trial by jury, Reuters reported.

A fourth man, who is suspected of running an illegal fishing network in the Javari Valley region, was named as the mastermind in January, although he has yet to be formally charged.

‘I am here in resistance’ Listen to Bruno Pereira’s last voice note to Survival International. 

For those who cover or live in that region, the killings underscored the increasingly risky environment.

“I was not surprised Dom and Bruno were killed. A friend of mine, Ari Uru-eu-wau-wau, was murdered three years ago too,” said Surui, who lives in Rodoñia, another Amazonian state.

Her struggle to save the Amazon with her mother, Neidinha Surui, was made into a 2021 film, Believing in a New World.

“People outside Brazil have to realize the damage that these gangs are doing to the Amazon,” she said.

In the wake of the Phillips killing, The Guardian and about a dozen other international media organizations investigated organized crime and the theft of natural resources in the Amazon.

The joint project was arranged by Forbidden Stories, a Paris-based nonprofit dedicated to completing the work of journalists killed for their work.

Sarah Shenker, a campaigner for Survival International, which campaigns for Indigenous people’s rights, was a close friend of Phillips and Pereira.

She says their deaths left her “shocked and devastated.”

“The difference here is that Bruno and Dom were not Indigenous and Bruno was not from the area. Some non-Indigenous people were killed. It sets a sort of difference with the killings of Indigenous,” she told VOA.

“People thought the gunmen would not go as far as to kill non-Indigenous people, maybe they would not enjoy the same impunity as if they killed Indigenous people, but clearly they did go that far.”

Shenker said she had received threats from gunmen while working to protect Indigenous rights from illegal loggers.

“We are questioned and threatened. Gunmen sometimes fire shots because they don’t want activists to protect Indigenous land. They just want to steal Indigenous land. But we have to carry on. This is one of the most important fights of our time.”

Jonathan Watts, The Guardian’s global environmental editor, is one of the contributors to the book Phillips and Pereira were working on.

Phillips had completed half of How to Save the Amazon: Ask the People Who Know, before he was killed. Watts and other journalists hope they can finish the book as they mark the journalist’s death and that of Pereira.

‘The dangers are immense’

“I think obviously as we have seen, horrifically with the case of Dom Phillips, the dangers are immense. It is unusual for a journalist to be killed in the [Amazon] forest.  But it is becoming more dangerous as organized crime increases its presence in the region,” Watts said in a telephone interview with VOA.

“In the past, there was crime, but there was not big narco gangs as it is today. There are suspicions that they are linked to the illegal fishing gangs which were responsible for the deaths of Dom and Bruno,” Watts said.

He said environmental campaigners who stand in the way of “extractive industries” like logging or illegal fishing face the same dangers as war reporters.

“I think the risk is like being a war reporter. It is a toll on a scale with a war and we lose about 300 per year, according to Global Witness,” Watts said.

Global Witness, an NGO that challenges abuses of power that threaten human rights and the environment, published a report in May that said since 2012, 1,733 of what it terms environmental defenders had been killed. The most dangerous countries: Brazil, Mexico and Colombia.

Environmental journalists who often accompanied activists like Pereira also ran the same risks as war reporters, Watts said.

“Sometimes being an environment reporter has similarities with being a war reporter. By being with a target or traveling with a target, as in the case of Dom, you can accidentally become a witness to a crime.”

Figures from the Brazilian Forum on Public Safety showed that with more than 8,000 deaths, the rate of intentional lethal crime in the Amazon was more than 50% higher than the rest of the country in 2022, The Guardian reported, making it a murder rate similar to Mexico.

In Amazonas state, where Phillips and Pereira were among 1,432 people killed last year, the murder rate was 74% above the national average. 
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While judges, lawyers and support staff at the federal courthouse in Concord, New Hampshire, keep the American justice system buzzing, thousands of humble honeybees on the building’s roof are playing their part in a more important task — feeding the world. 

The Warren B. Rudman courthouse is one of several federal facilities around the country participating in the General Services Administration’s Pollinator Initiative, a government program aimed at assessing and promoting the health of bees and other pollinators, which are critical to life on Earth. 

“Anybody who eats food, needs bees,” said Noah Wilson-Rich, co-founder, CEO and chief scientific officer of the Boston-based Best Bees company, which contracts with the government to take care of the honeybee hives at the New Hampshire courthouse and at some other federal buildings. 

Bees help pollinate the fruits and vegetables that sustain humans, he said. They pollinate hay and alfalfa, which feed cattle that provide the meat we eat. And they promote the health of plants that, through photosynthesis, give us clean air to breathe. 

Yet the busy insects that contribute an estimated $25 billion to the U.S. economy annually are under threat from diseases, agricultural chemicals and habitat loss that kill about half of all honeybee hives annually. Without human intervention, including beekeepers creating new hives, the world could experience a bee extinction that would lead to global hunger and economic collapse, Wilson-Rich said. 

The pollinator program is part of the federal government’s commitment to promoting sustainability, which includes reducing greenhouse gas emissions and promoting climate resilient infrastructure, said David Johnson, the General Services Administration’s sustainability program manager for New England. 

The GSA’s program started last year with hives at 11 sites. 

Some of those sites are no longer in the program. Hives placed at the National Archives building in Waltham, Massachusetts, last year did not survive the winter. 

Since then, other sites were added. Two hives, each home to thousands of bees, were placed on the roof of the Rudman building in March. 

The program is collecting data to find out whether the honeybees, which can fly 3 to 5 miles from the roof in their quest for pollen, can help the health of not just the plants on the roof, but also of the flora in the entire area, Johnson said. 

“Honeybees are actually very opportunistic,” he said. “They will feed on a lot of different types of plants.” 

The program can help identify the plants and landscapes beneficial to pollinators and help the government make more informed decisions about what trees and flowers to plant on building grounds. 

Best Bees tests the plant DNA in the honey to get an idea of the plant diversity and health in the area, Wilson-Rich said, and they have found that bees that forage on a more diverse diet seem to have better survival and productivity outcomes. 

Other federal facilities with hives include the Centers for Medicare and Medicaid Services headquarters in Baltimore; the federal courthouse in Hammond, Indiana; the Federal Archives Records Center in Chicago; and the Denver Federal Center. 

The federal government isn’t alone in its efforts to save the bees. The hives placed at federal sites are part of a wider network of about 1,000 hives at home gardens, businesses and institutions nationwide that combined can help determine what’s helping the bees, what’s hurting them and why. 

The GSA’s Pollinator Initiative is also looking to identify ways to keep the bee population healthy and vibrant and model those lessons at other properties — both government and private sector — said Amber Levofsky, the senior program advisor for the GSA’s Center for Urban Development. 

“The goal of this initiative was really aimed at gathering location-based data at facilities to help update directives and policies to help facilities managers to really target pollinator protection and habitat management regionally,” she said. 

And there is one other benefit to the government honeybee program that’s already come to fruition: the excess honey that’s produced is donated to area food banks. 
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