Day: June 21, 2023

US CDC Advisers Recommend RSV Shots Be Available to Older Adults

A panel of advisers to the U.S. Centers for Disease Control and Prevention (CDC) on Wednesday recommended that new vaccines from Pfizer and GSK to prevent severe respiratory syncytial virus (RSV) infections be available to older adults in the U.S. but stopped short of saying all of them should get the shots.

In two separate votes, the CDC’s Advisory Committee on Immunization Practices (ACIP) said that people aged 60 and older may receive the RSV shots after consulting with a health care provider.

It was not the strongest recommendation that the ACIP could have made for the shots. Some committee members wanted a broader recommendation, but others had concerns that there was not enough data about how effective the vaccines are in people over age 75 and other high-risk groups.

“Those who are at high risk for disease and for high risk for hospitalizations and death were actually not included in the trials,” said committee member Dr. Helen Keipp Talbot. “The patient population that participated in the study were younger and healthier and had fewer comorbid conditions, were not immunocompromised and were not living in nursing homes.”

The CDC’s director needs to sign off on the recommendation before the vaccines can be made available. Both drugmakers have said they expected to be able to supply the shots ahead of the RSV season later this year.

RSV usually causes mild cold-like symptoms but can also lead to serious illness and hospitalization. It is estimated to be responsible for 14,000 deaths annually in adults aged 65 and older in the United States, according to government data.

During the meeting, the companies presented data on whether one inoculation could remain effective over the course of two RSV seasons compared with protection seen with an annual shot.

In older adults, the efficacy of Pfizer’s vaccine in preventing lower respiratory tract disease with three or more symptoms fell from 88.9% at the end of the first season to 78.6% through the middle of a second RSV season. Efficacy fell to 48.9% from about 65% for less severe forms of the disease in that age group.

With the GSK vaccine, efficacy in preventing severe disease defined by three or more symptoms fell to 84.6% through the middle of the second RSV season, from about 94% at the end of first in older adults. Efficacy of the vaccine in preventing lower respiratory tract disease fell to 77.3% from 82.6% at the end of the first season in older adults.

The U.S. Food and Drug Administration last month approved the first RSV vaccine from GSK, branded as Arexvy, and later Pfizer’s Abrysvo for people aged 60 and older to protect them from lower respiratory tract disease caused by the virus.

Pfizer and GSK have said they expect RSV vaccines to eventually become multibillion-dollar sellers.

For this year, GSK has said it expects the U.S. market to be in the range of 10 million to 15 million people, a small fraction of the size of the expected flu or COVID-19 market for 2023.

At the meeting, GSK said it expects to price its shot between $200 and $295 a dose. Pfizer provided the CDC with a price range of $180 to $270 per dose but would not guarantee that its final price would fall within that range, saying it was in the middle of competitive price negotiations on the shots.

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Summer Solstice Has Arrived

In astronomical terms, summer begins Wednesday with the arrival of the summer solstice, which marks the longest day of the year for everyone north of the equator. 

This year, the summer solstice falls at exactly 10:57 a.m. EDT, when the sun is directly over the Tropic of Cancer. South of the equator, the same time marks the astronomical start of winter. 

On two moments each year, Earth’s axis tilts the most toward the sun. The hemisphere that tilts closer to the sun experiences its longest day, whereas the hemisphere that tilts away from the sun experiences its longest night. 

The summer solstice takes place between June 20 and 22 each year. By meteorological standards, summer for the Northern Hemisphere begins on June 1. 

This year, the winter solstice will take place on December 21, marking the shortest day of the year for the Northern Hemisphere. 

On the summer solstice, the amount of sunlight people experience depends on how far north they are. The northernmost latitudes experience a full 24 hours of sunlight. By comparison, most of the United States will experience between 14 and 16 hours of sunlight. 

The word solstice comes from the Latin words sol (sun) and sistere (to stand still).

Nowadays, the summer solstice comes and goes with little significance to many. 

But for millennia, people around the world celebrated the summer solstice in various ways. Some still take part in festivities. 

The most well-known celebration takes place at 5,000-year-old Stonehenge in England.

Crowds of about 10,000 people — including druids and pagans — often gather at Stonehenge to watch as the rising sun aligns perfectly with the complex’s Heel Stone, which stands outside the main circle. 

In Scandinavian countries, Midsummer festivals mark the summer solstice. In Sweden, people dance around a maypole and feast on herring and vodka. 

Some Alaskans celebrate with midnight baseball, and in Iceland, some celebrate with late-night hiking and golf.

Meanwhile in Ukraine, celebrations honor John the Baptist, known as Ivan Kupala. 

This year, astronomical summer concludes with the autumn equinox on September 23. 

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US OKs Chicken Made From Cultivated Cells, Nation’s First ‘Lab-Grown’ Meat

For the first time, U.S. regulators on Wednesday approved the sale of chicken made from animal cells, allowing two California companies to offer “lab-grown” meat to the nation’s restaurant tables and, eventually, supermarket shelves. 

The Agriculture Department gave the green light to Upside Foods and Good Meat, firms that had been racing to be the first in the U.S. to sell meat that doesn’t come from slaughtered animals — what’s now being referred to as “cell-cultivated” or “cultured” meat as it emerges from the laboratory and arrives on dinner plates. 

The move launches a new era of meat production aimed at eliminating harm to animals and drastically reducing the environmental impacts of grazing, growing feed for animals and animal waste. 

“Instead of all of that land and all of that water that’s used to feed all of these animals that are slaughtered, we can do it in a different way,” said Josh Tetrick, co-founder and chief executive of Eat Just, which operates Good Meat. 

The companies received approvals for federal inspections required to sell meat and poultry in the U.S. The action came months after the U.S. Food and Drug Administration deemed that products from both companies are safe to eat. A manufacturing company called Joinn Biologics, which works with Good Meat, was also cleared to make the products. 

Cultivated meat is grown in steel tanks, using cells that come from a living animal, a fertilized egg or a special bank of stored cells. In Upside’s case, it comes out in large sheets that are then formed into shapes like chicken cutlets and sausages. Good Meat, which already sells cultivated meat in Singapore, the first country to allow it, turns masses of chicken cells into cutlets, nuggets, shredded meat and satays. 

But don’t look for this novel meat in U.S. grocery stores anytime soon. Cultivated chicken is much more expensive than meat from whole, farmed birds and cannot yet be produced on the scale of traditional meat, said Ricardo San Martin, director of the Alt:Meat Lab at University of California Berkeley. 

The companies plan to serve the new food first in exclusive restaurants: Upside has partnered with a San Francisco restaurant called Bar Crenn, while Good Meat dishes will be served at a Washington, D.C., restaurant run by chef and owner Jose Andrés. 

Company officials are quick to note the products are meat, not substitutes like the Impossible Burger or offerings from Beyond Meat, which are made from plant proteins and other ingredients. 

Globally, more than 150 companies are focusing on meat from cells, not only chicken but pork, lamb, fish and beef, which scientists say has the biggest impact on the environment. 

Upside, based in Berkeley, operates a 70,000-square-foot building in nearby Emeryville. On a recent Tuesday, visitors entered a gleaming commercial kitchen where chef Jess Weaver was sauteeing a cultivated chicken filet in a white wine butter sauce with tomatoes, capers and green onions. 

The finished chicken breast product was slightly paler than the grocery store version. Otherwise it looked, cooked, smelled and tasted like any other pan-fried poultry. 

“The most common response we get is, ‘Oh, it tastes like chicken,'” said Amy Chen, Upside’s chief operating officer. 

Good Meat, based in Alameda, operates a 100,000-square-foot plant, where chef Zach Tyndall dished up a smoked chicken salad on a sunny June afternoon. He followed it with a chicken “thigh” served on a bed of potato puree with a mushroom-vegetable demi-glace and tiny purple cauliflower florets. The Good Meat chicken product will come pre-cooked, requiring only heating to use in a range of dishes. 

‘Ick factor’

Chen acknowledged that many consumers are skeptical, even squeamish, about the thought of eating chicken grown from cells. 

“We call it the ‘ick factor,'” she said. 

The sentiment was echoed in a recent poll conducted by the Associated Press and the NORC Center for Public Affairs Research. Half of U.S. adults said that they are unlikely to try meat grown using cells from animals. When asked to choose from a list of reasons for their reluctance, most who said they’d be unlikely to try it said “it just sounds weird.” About half said they don’t think it would be safe. 

But once people understand how the meat is made, they’re more accepting, Chen said. And once they taste it, they’re usually sold. 

“It is the meat that you’ve always known and loved,” she said. 

Cultivated meat begins with cells. Upside experts take cells from live animals, choosing those most likely to taste good and to reproduce quickly and consistently, forming high-quality meat, Chen said. Good Meat products are created from a master cell bank formed from a commercially available chicken cell line. 

Once the cell lines are selected, they’re combined with a broth-like mixture that includes the amino acids, fatty acids, sugars, salts, vitamins and other elements cells need to grow. Inside the tanks, called cultivators, the cells grow, proliferating quickly. At Upside, muscle and connective tissue cells grow together, forming large sheets. After about three weeks, the sheets of poultry cells are removed from the tanks and formed into cutlets, sausages or other foods. Good Meat cells grow into large masses, which are shaped into a range of meat products. 

Challenges

Both firms emphasized that initial production will be limited. The Emeryville facility can produce up to 50,000 pounds of cultivated meat products a year, though the goal is to expand to 400,000 pounds per year, Upside officials said. Good Meat officials wouldn’t estimate a production goal. 

By comparison, the U.S. produces about 50 billion pounds of chicken per year. 

It could take a few years before consumers see the products in more restaurants and seven to 10 years before they hit the wider market, said Sebastian Bohn, who specializes in cell-based foods at CRB, a Missouri firm that designs and builds facilities for pharmaceutical, biotech and food companies. 

Cost will be another sticking point. Neither Upside nor Good Meat officials would reveal the price of a single chicken cutlet, saying only that it’s been reduced by orders of magnitude since the firms began offering demonstrations. Eventually, the price is expected to mirror high-end organic chicken, which sells for up to $20 per pound. 

San Martin said he’s concerned that cultivated meat may wind up being an alternative to traditional meat for rich people, but will do little for the environment if it remains a niche product. 

“If some high-end or affluent people want to eat this instead of a chicken, it’s good,” he said. “Will that mean you will feed chicken to poor people? I honestly don’t see it.” 

Tetrick said he shares critics’ concerns about the challenges of producing an affordable, novel meat product for the world. But he emphasized that traditional meat production is so damaging to the planet it requires an alternative — preferably one that doesn’t require giving up meat all together. 

“I miss meat,” said Tetrick, who grew up in Alabama eating chicken wings and barbecue. “There should be a different way that people can enjoy chicken and beef and pork with their families.” 

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Drone Photo and Video Competition Shows Stunning Views of Earth

Drone photographers and videographers from around the world submitted more than 65,000 pieces of work in an annual online competition. VOA’s Julie Taboh highlights some of the winning entries. Editing: Adam Greenbaum 

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