Day: April 24, 2023

Scientists said Monday they have developed the first mobile printer that can produce thumbnail-sized patches able to deliver mRNA COVID-19 vaccines, hoping the tabletop device will help immunize people in remote regions.

While many hurdles remain and the 3D printer is likely years away from becoming available, experts hailed the “exciting” finding.

The device prints 2-centimeter-wide patches that each contain hundreds of tiny needles that administer a vaccine when pressed against the skin.

These “microneedle patches” offer a range of advantages over traditional jabs in the arm, including that they can be self-administered, are relatively painless, could be more palatable to the vaccine-hesitant and can be stored at room temperature for long periods of time.

The popular mRNA COVID-19 vaccines from Pfizer and Moderna need to be refrigerated, which has caused distribution complications — particularly in developing countries that have condemned the unequal distribution of doses during the pandemic.

The new printer was tested with the Pfizer and Moderna jabs, according to a study in the journal Nature Biotechnology, but the goal of the international team of researchers behind it is for it to be adapted to whatever vaccines are needed.

Robert Langer, co-founder of Moderna and one of the study’s authors, told AFP that he hoped the printer could be used for “the next COVID, or whatever crisis occurs.” 

Ana Jaklenec, a study author also from the Massachusetts Institute of Technology, said the printer could be sent to areas such as refugee camps or remote villages to “quickly immunize the local population,” in the event of a fresh outbreak of a disease like Ebola.

Vacuum-sealed

Microneedle patch vaccines are already under development for COVID-19 and a range of other diseases, including polio, measles and rubella.

But the patches have long struggled to take off because producing them is an expensive, laborious process often involving large machines for centrifugation. 

To shrink that process down, the researchers used a vacuum chamber to suck the printer “ink” into the bottom of their patch molds, so it reaches the points of the tiny needles.

The vaccine ink is made up of lipid nanoparticles containing mRNA vaccine molecules, as well as a polymer similar to sugar water.

Once allowed to dry, the patches can be stored at room temperature for at least six months, the study found. The patches even survived a month at a balmy 37 degrees Celsius (99 Fahrenheit).

Mice that were given a vaccine patch produced a similar level of antibody response to others immunized via a traditional injection, the study said.

The printed patches are currently being tested on primates, which if successful would lead to trials on humans. 

‘A real breakthrough’?

The printer can make 100 patches in 48 hours. But modelling suggested that — with improvements — it could potentially print thousands a day, the researchers said.

“And you can have more than one printer,” Langer added.

Joseph DeSimone, a chemist at Stanford University not involved in the research, said that “this work is particularly exciting as it realizes the ability to produce vaccines on demand.” 

“With the possibility of scaling up vaccine manufacturing and improved stability at higher temperatures, mobile vaccine printers can facilitate widespread access to RNA vaccines,” said DeSimone, who has invented his own microneedle patches.

Antoine Flahault, director of the Institute of Global Health at the University of Geneva, said that production and access to vaccines could be “transformed through such a printer.”

“It might become a real breakthrough,” he told AFP, while warning that this depended on approval and mass production, which could take years.

Darrick Carter, a biochemist and CEO of U.S. biotech firm PAI Life Sciences, was less optimistic. 

He said that the field of microneedle patches had “suffered for 30 years” because no one had yet been able to scale up manufacturing in a cost-effective way.

“Until someone figures out the manufacturing scale-up issues for microneedle patches they will remain niche products,” he told AFP. 
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Twitter accounts operated by authoritarian governments in Russia, China and Iran are benefiting from recent changes at the social media company, researchers said Monday, making it easier for them to attract new followers and broadcast propaganda and disinformation to a larger audience. 

The platform is no longer labeling state-controlled media and propaganda agencies, and will no longer prohibit their content from being automatically promoted or recommended to users. Together, the two changes, both made in recent weeks, have supercharged the Kremlin’s ability to use the U.S.-based platform to spread lies and misleading claims about its invasion of Ukraine, U.S. politics and other topics. 

Russian state media accounts are now earning 33% more views than they were just weeks ago, before the change was made, according to findings released Monday by Reset, a London-based non-profit that tracks authoritarian governments’ use of social media to spread propaganda. Reset’s findings were first reported by The Associated Press. 

The increase works out to more than 125,000 additional views per post. Those posts included ones suggesting the CIA had something to do with the September 11, 2001, attacks on the U.S., that Ukraine’s leaders are embezzling foreign aid to their country, and that Russia’s invasion of Ukraine was justified because the U.S. was running clandestine biowarfare labs in the country. 

State media agencies operated by Iran and China have seen similar increases in engagement since Twitter quietly made the changes. 

The about-face from the platform is the latest development since billionaire Elon Musk purchased Twitter last year. Since then, he’s ushered in a confusing new verification system and laid off much of the company’s staff, including those dedicated to fighting misinformation, allowed back neo-Nazis and others formerly suspended from the site, and ended the site’s policy prohibiting dangerous COVID-19 misinformation. Hate speech and disinformation have thrived. 

Before the most recent change, Twitter affixed labels reading “Russia state-affiliated media” to let users know the origin of the content. It also throttled back the Kremlin’s online engagement by making the accounts ineligible for automatic promotion or recommendation—something it regularly does for ordinary accounts as a way to help them reach bigger audiences. 

The labels quietly disappeared after National Public Radio and other outlets protested Musk’s plans to label their outlets as state-affiliated media, too. NPR then announced it would no longer use Twitter, saying the label was misleading, given NPR’s editorial independence, and would damage its credibility. 

Reset’s conclusions were confirmed by the Atlantic Council’s Digital Forensic Research Lab (DFRL), where researchers determined the changes were likely made by Twitter late last month. Many of the dozens of previously labeled accounts were steadily losing followers since Twitter began using the labels. But after the change, many accounts saw big jumps in followers. 

RT Arabic, one of Russia’s most popular propaganda accounts on Twitter, had fallen to less than 5,230,000 followers on January 1, but rebounded after the change was implemented, the DFRL found. It now has more than 5,240,000 followers. 

Before the change, users interested in seeking out Kremlin propaganda had to search specifically for the account or its content. Now, it can be recommended or promoted like any other content. 

“Twitter users no longer must actively seek out state-sponsored content in order to see it on the platform; it can just be served to them,” the DFRL concluded. 

Twitter did not respond to questions about the change or the reasons behind it. Musk has made past comments suggesting he sees little difference between state-funded propaganda agencies operated by authoritarian strongmen and independent news outlets in the west.

“All news sources are partially propaganda,” he tweeted last year, “some more than others.”
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Nine European countries held a summit on Monday aimed at scaling up wind power generation in the North Sea, spurred by the fallout from the war in Ukraine and the push for renewables. 

“We’ve seen over the past months what the impact is if you are too dependent on outsiders for the supply of energy,” said Belgian Prime Minister Alexander De Croo, who hosted the meeting in the coastal town of Ostend. 

The leaders of EU members France, Germany, Ireland, Denmark, the Netherlands and Luxembourg, along with European Commission chief Ursula von der Leyen, attended the summit. 

Norway and Britain also participated, with the latter represented by UK Energy Security Secretary Grant Shapps. 

In a joint op-ed published in Politico, the leaders of the nine nations emphasized the need to build more offshore wind turbines “to reach our climate goals, and to rid ourselves of Russian gas, ensuring a more secure and independent Europe.” 

Several leaders pointed to the need also to ensure security of offshore wind farms and their interconnectors, in the wake of recent reports of a Russian spy ship in the North Sea and last year’s sabotage of the Nord Stream gas pipelines in the Baltic Sea. 

De Croo said North Sea infrastructure, including turbines and undersea cables “are prone to sabotage or to espionage” and the topic was “an extremely important one” at the summit.

The summit’s collective goal, stated by all the leaders, is to boost offshore wind power generation to 120 gigawatts by 2030 — from just 30 GW today — and at least 300 GW by 2050.

They recognized the size of the task requires massive investment and that standardizing equipment is needed to bring down costs and timescales.

A key point, hammered by French President Emmanuel Macron, is to ensure the supply chain for the push for more North Sea wind power is anchored in Europe, rather than elsewhere, and that the jobs created are there.

“We want to secure our industrial chain, because it’s important to deploy this offshore wind power but we don’t want to repeat the errors we’ve sometimes committed in the past, of deploying equipment made on the other side of the world,” he said.

The comment appeared to be directed at China, which currently dominates the supply of critical elements, such as rare earth metals. The European Union is seeking to shift away from that reliance on China by bolstering its own industries.

German Chancellor Olaf Scholz said the “very important” summit underscored the potential to greatly expand renewable energy from the North Sea. 

Industry criticism 

WindEurope, an organization that promotes wind energy across Europe, believes the summit’s ambitions are achievable. But it highlighted a lack of “adequate funding mechanisms” and recruitment in the sector.

The organization says Europe needs to build the offshore infrastructure to add 20 GW in output per year, yet the sector currently has capacity for just seven GW annually, with supply chain bottlenecks for cables, substations and foundations, and in the availability of offshore support vessels.

Investment to get Europe where it wants to be is huge: The EU has calculated the cost of reaching 300 GW in offshore energy production by 2050 at $900 billion.

Britain has the biggest fleet of offshore wind farms, 45 of them, currently producing 14 GW, with plans to expand capacity to 50 GW by 2030.

Germany’s 30 wind farms produce 8 GW, followed by the Netherlands with 2.8 GW and Denmark and Belgium both with 2.3 GW.

The other participating countries produce less than a gigawatt from their existing installations but share ambitions to greatly ramp up wind energy capacity. 
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The AI bot ChatGPT has passed exams, written poetry, and deployed in newsrooms, and now politicians are seeking it out — but experts are warning against rapid uptake of a tool also famous for fabricating “facts.”

The chatbot, released last November by U.S. firm OpenAI, has quickly moved center stage in politics — particularly as a way of scoring points.

Japanese Prime Minister Fumio Kishida recently took a direct hit from the bot when he answered some innocuous questions about health care reform from an opposition MP.

Unbeknownst to the PM, his adversary had generated the questions with ChatGPT. He also generated answers that he claimed were “more sincere” than Kishida’s.

The PM hit back that his own answers had been “more specific.”

French trade union boss Sophie Binet was on-trend when she drily assessed a recent speech by President Emmanuel Macron as one that “could have been done by ChatGPT.”

But the bot has also been used to write speeches and even help draft laws. 

“It’s useful to think of ChatGPT and generative AI in general as a cliche generator,” David Karpf of George Washington University in the U.S. said during a recent online panel. 

“Most of what we do in politics is also cliche generation.”

‘Limited added value’

Nowhere has the enthusiasm for grandstanding with ChatGPT been keener than in the United States.

Last month, Congresswoman Nancy Mace gave a five-minute speech at a Senate committee enumerating potential uses and harms of AI — before delivering the punchline that “every single word” had been generated by ChatGPT.

Local U.S. politician Barry Finegold had already gone further though, pronouncing in January that his team had used ChatGPT to draft a bill for the Massachusetts Senate.

The bot reportedly introduced original ideas to the bill, which is intended to rein in the power of chatbots and AI.

Anne Meuwese from Leiden University in the Netherlands wrote in a column for Dutch law journal RegelMaat last week that she had carried out a similar experiment with ChatGPT and also found that the bot introduced original ideas.

But while ChatGPT was to some extent capable of generating legal texts, she wrote that lawmakers should not fall over each other to use the tool.

“Not only is much still unclear about important issues such as environmental impact, bias and the ethics at OpenAI … the added value also seems limited for now,” she wrote.

Agitprop bots

The added value might be more obvious lower down the political food chain, though, where staffers on the campaign trail face a treadmill of repetitive tasks.

Karpf suggested AI could be useful for generating emails asking for donations — necessary messages that were not intended to be masterpieces.

This raises an issue of whether the bots can be trained to represent a political point of view.

ChatGPT has already provoked a storm of controversy over its apparent liberal bias — the bot initially refused to write a poem praising Donald Trump but happily churned out couplets for his successor as U.S. President Joe Biden.

Billionaire magnate Elon Musk has spied an opportunity. Despite warning that AI systems could destroy civilization, he recently promised to develop TruthGPT, an AI text tool stripped of the perceived liberal bias.

Perhaps he needn’t have bothered. New Zealand researcher David Rozado already ran an experiment retooling ChatGPT as RightWingGPT — a bot on board with family values, liberal economics and other right-wing rallying cries.

“Critically, the computational cost of trialling, training and testing the system was less than $300,” he wrote on his Substack blog in February.

Not to be outdone, the left has its own “Marxist AI.”

The bot was created by the founder of Belgian satirical website Nordpresse, who goes by the pseudonym Vincent Flibustier.

He told AFP his bot just sends queries to ChatGPT with the command to answer as if it were an “angry trade unionist.”

The malleability of chatbots is central to their appeal but it goes hand-in-hand with the tendency to generate untruths, making AI text generators potentially hazardous allies for the political class.

“You don’t want to become famous as the political consultant or the political campaign that blew it because you decided that you could have a generative AI do [something] for you,” said Karpf. 
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April 24 – April 30, is World Immunization Week.

The theme of this year’s observance is “The Big Catch-Up.”

The idea is for everyone, especially children, to catch up on the vaccinations they might have missed during the COVID outbreak.

The ultimate goal of World Immunization Week, according the World Health Organization, is for more children, adults and their communities to be protected from vaccine-preventable diseases, like polio and measles.

 
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Air pollution still causes more than 1,200 premature deaths a year in under 18’s across Europe and increases the risk of chronic disease later in life, the EU environmental agency said Monday.   

Despite recent improvements, “the level of key air pollutants in many European countries remain stubbornly above World Health Organization” (WHO) guidelines, particularly in central-eastern Europe and Italy, said the EEA after a study in over 30 countries, including the 27 members of the European Union.   

The report did not cover the major industrial nations of Russia, Ukraine and the United Kingdom, suggesting the overall death tolls for the continent could be higher.   

The EEA announced last November that 238,000 people died prematurely because of air pollution in 2020 in the EU, plus Iceland, Liechtenstein, Norway, Switzerland and Turkey.   

“Air pollution causes over 1,200 premature deaths per year in people under the age of 18 in Europe and significantly increases the risk of disease later in life,” the agency said.   

The study was the agency’s first to focus specifically on children.   

“Although the number of premature deaths in this age group is low relative to the total for the European population estimated by EEA each year, deaths early in life represent a loss of future potential and come with a significant burden of chronic illness, both in childhood and later in life,” the agency said.  

It urged authorities to focus on improving air quality around schools and nurseries as well as sports facilities and mass transport hubs.   

“After birth, ambient air pollution increases the risk of several health problems, including asthma, reduced lung function, respiratory infections and allergies,” the report noted.   

7 million dead annually 

Poor air quality can also “aggravate chronic conditions like asthma, which afflicts nine percent of children and adolescents in Europe, as well as increasing the risk of some chronic diseases later in adulthood.”   

Ninety-seven percent of the urban population were in 2021 exposed to air that did not meet WHO recommendations, according to figures released Monday.   

The EEA had last year underlined that the EU was on track to meet its target of reducing premature deaths by 50% by 2030 compared with 2005.   

In the early 1990s, fine particulates caused nearly a million premature deaths a year in the 27 EU nations. That fell to 431,000 in 2005.   

The situation in Europe looks better than for much of the planet, says the WHO, which blames air pollution for 7 million deaths globally each year, almost as many as for cigarette smoking or bad diets.   

It took until September 2021 to reach agreement to tighten limits set for major pollutants back in 2005.   

In Thailand alone, where toxic smog chokes parts of the country, health officials said last week that 2.4 million people had sought hospital treatment for medical problems linked to air pollution since the start of the year.   

Fine particulate matter, primarily from cars and trucks and which can penetrate deeply into the lungs, is considered the worst air pollutant, followed by nitrogen dioxide and ozone. 
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