Day: October 5, 2022

The deaths of dozens of children in Gambia from kidney injuries may be linked to contaminated cough and cold syrups made by an Indian drug manufacturer, the World Health Organization said Wednesday. 

WHO Director-General Tedros Adhanom Ghebreyesus told reporters that the U.N. agency was investigating along with Indian regulators and the drugmaker, New Delhi-based Maiden Pharmaceuticals.  

Maiden declined to comment on the alert, while calls and Reuters messages to the Drugs Controller General of India went unanswered. India’s health ministry also did not immediately respond to a request for comment.  

The WHO issued a medical product alert asking regulators to remove Maiden Pharmaceuticals goods from the market. The products may have been distributed elsewhere through informal markets but had so far only been identified in Gambia, the WHO said in its alert.  

The alert covers four products: Promethazine Oral Solution, Kofexmalin Baby Cough Syrup, Makoff Baby Cough Syrup and Magrip N Cold Syrup.  

Lab analysis confirmed unacceptable amounts of diethylene glycol and ethylene glycol, which can be toxic when consumed, the WHO said. Gambia’s government said last month that it had also been investigating the deaths, as a spike in cases of acute kidney injury among children younger than 5 was detected in late July.  

Several children in Gambia began falling ill with kidney problems three to five days after taking a locally sold paracetamol syrup. By August, 28 had died, but health authorities said the toll would likely rise. Now 66 are dead, WHO said  Wednesday. 

The deaths have shaken the tiny West African nation, which is also dealing with multiple health emergencies, including measles and malaria. 

Maiden Pharmaceuticals manufactures medicines at its facilities in India, which it then sells domestically as well as exporting them to countries in Asia, Africa and Latin America, according to its website. 
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For the first time in 20 years, a Russian cosmonaut rocketed from the U.S. on Wednesday, launching to the International Space Station alongside NASA and Japanese astronauts despite tensions over the war in Ukraine. 

Their SpaceX flight was delayed by Hurricane Ian, which ripped across the state last week. 

“I hope with this launch we will brighten up the skies over Florida a little bit for everyone,” said the Japan Space Agency’s Koichi Wakata, who is making his fifth spaceflight. 

Joining him on a five-month mission are three new to space: Marine Col. Nicole Mann, the first Native American woman to orbit Earth; Navy Capt. Josh Cassada; and Russia’s lone female cosmonaut, Anna Kikina. 

“Awesome!” said Mann as they reached orbit. “That was a smooth ride uphill. You’ve got three rookies who are pretty happy to be floating in space right now.” 

They’re due to arrive at the space station Thursday, 29 hours after a noon departure from NASA’s Kennedy Space Center, and won’t be back on Earth until March. They’re replacing a U.S.-Italian crew that arrived in April. 

Kikina is the Russian Space Agency’s exchange for NASA’s Frank Rubio, who launched to the space station two weeks ago from Kazakhstan aboard a Soyuz rocket. He flew up with two cosmonauts. 

The space agencies agreed over the summer to swap seats on their flights in order to ensure a continuous U.S. and Russian presence aboard the 260-mile-high (420-kilometer-high) outpost. The barter was authorized even as global hostilities mounted over Russia’s invasion of Ukraine in late February. The next crew exchange is in the spring. 

Shortly before liftoff, NASA Administrator Bill Nelson said that the key reason for the seat exchange is safety — in case an emergency forces one capsule’s crew home, there would still be an American and Russian on board. 

In the meantime, Russia remains committed to the space station through at least 2024, Russia space official Sergei Krikalev assured reporters this week. Russia wants to build its own station in orbit later this decade, “but we know that it’s not going to happen very quick and so probably we will keep flying” with NASA until then, he said. 

Beginning with Krikalev in 1994, NASA started flying cosmonauts on its space shuttles, first to Russia’s Mir space station and then to the fledgling space station. The 2003 Columbia reentry disaster put an end to it. But U.S. astronauts continued to hitch rides on Russian rockets for tens of millions of dollars per seat. 

Kakina is only the fifth Russian woman to rocket off the planet. She said she was surprised to be selected for the seat swap after encountering “many tests and obstacles” during her decade of training. “But I did it. I’m lucky maybe. I’m strong,” she said. 

Mann is a member of the Wailacki of the Round Valley Indian Tribes in California, and taking up her mother’s dream catcher, a small traditional webbed hoop believed to offer protection. Retired NASA astronaut John Herrington of the Chickasaw Nation became the first Native American in space in 2002. 

“I am very proud to represent Native Americans and my heritage,” Mann said before the flight, adding that everyone on her crew has a unique background. “It’s important to celebrate our diversity and also realize how important it is when we collaborate and unite, the incredible accomplishments that we can have.” 

As for the war in Ukraine, Mann said all four have put politics and personal beliefs aside, “and it’s really cool how the common mission of the space station just instantly unites us.” 

Added Cassada: “We have an opportunity to be an example for society on how to work together and live together and explore together.” 

Elon Musk’s SpaceX has now launched eight crews since 2020: six for NASA and two private groups. Boeing, NASA’s other contracted taxi service, plans to make its first astronaut flight early next yea r, after delays to fix software and other issues that cropped up on test flights. 

 
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The Royal Swedish Academy of Sciences announced Wednesday three scientists won the Nobel Prize in chemistry for “the development of click chemistry and bioorthogonal chemistry.”

The prize and its $900,000 award went equally to Carolyn Bertozzi and Barry Sharpless of the United States and Morten Meldal of Denmark.

For Sharpless, it is his second Nobel Prize in chemistry after being awarded the honor in 2001.

The academy said Meldal and Sharpless each independently presented a chemical reaction that is now used widely to develop pharmaceuticals and materials, and for mapping DNA.

Bertozzi developed the field further with reactions that function inside living things, the academy said, with applications that include exploring cells and tracking biological processes.

The Nobel Prize for medicine and for physics were awarded earlier this week, with the literature prize and the Nobel Peace Prize due to be announced Thursday and Friday.

Some information for this report came from The Associated Press, Agence France-Presse and Reuters.
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Enzymes found in the saliva of wax worms can degrade one of the most common forms of plastic waste, according to research published Tuesday that could open up new ways of dealing with plastic pollution.

Humans produce some 400 million metric tons of plastic waste each year despite international drives to reduce single-use plastics and to increase recycling.

Around a third is polyethylene, a tough plastic thanks to its structure, which traditionally requires heating or radiation before it starts to break down.

There have been several studies showing that microorganisms can release enzymes that start the degradation process on polyethylene, but the process has until now taken months each time.

But the enzymes contained in the saliva of the wax worm moth (Galleria mellonella) can act in only a few hours, Tuesday’s research showed.

Researcher Federica Bertocchini, an avid beekeeper, said she originally stumbled on the idea that this small caterpillar had unusual powers when storing honeycombs a few years ago.

“At the end of the season, usually beekeepers put some empty beehives in a storage room, to put them back in the field in the spring,” she told AFP.

“One year I did that, and I found my stored honeycombs plagued with wax worms. In fact, that is their habitat.”

Bertocchini cleaned the honeycombs and put the worms in a plastic bag.

When she returned a short time later, she found the bag “riddled with holes.”

“That raised the question: Is it the result of munching, or is there a chemical modification? We checked that, doing proper lab experiments, and we found that the polyethylene had been oxidized,” she said.

In her latest research, Bertocchini, from Madrid’s Margarita Salas Centre for Biological Studies (CIB) and her colleagues analyzed proteins in the wax worm saliva and identified two enzymes that could break polyethylene down into small polymers in only a few hours at room temperature.

Writing in the journal Nature Communications they explained how they used another worm’s saliva as a control experiment, which produced no degradation compared with the wax worm.

Bertocchini said her team is still trying to figure out precisely how the worms degraded the plastic.

While the study authors stressed that much more research was needed before Tuesday’s findings could be implemented at any meaningful scale, there were a number of possible applications.

“We can imagine a scenario where these enzymes are used in an aqueous solution, and liters of this solution is poured over piles of collected plastic in a waste management facility,” Bertocchini said.

“We can also imagine small amounts that can reach more remote locations, like villages or small islands, where waste facilities are not available.”

She said that further down the line the solution could be used in individual houses, where each family could degrade their own plastic waste.
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