Day: August 30, 2017

‘Reprogrammed’ Stem Cells Fight Parkinson’s Disease in Monkeys

Scientists have successfully used “reprogrammed” stem cells to restore functioning brain cells in monkeys, raising hopes the technique could be used in the future to help patients with Parkinson’s disease.

Since Parkinson’s is caused by a lack of dopamine made by brain cells, researchers have long hoped to use stem cells to restore normal production of the neurotransmitter chemical.

Now, for the first time, Japanese researchers have shown that human induced pluripotent stem cells (iPS) can be administered safely and effectively to treat primates with symptoms of the debilitating disease.

So-called iPS cells are made by removing mature cells from an individual — often from the skin — and reprogramming them to behave like embryonic stem cells. They can then be coaxed into dopamine-producing brain cells.

The scientists from Kyoto University, a world-leader in iPS technology, said their experiment indicated that this approach could potentially be used for the clinical treatment of human patients with Parkinson’s.

In addition to boosting dopamine production, the tests showed improved movement in affected monkeys and no tumors in their brains for at least two years.

The human iPS cells used in the experiment worked whether they came from healthy individuals or Parkinson’s disease patients, the Japanese team reported in the journal Nature on Wednesday.

“This is extremely promising research demonstrating that a safe and highly effective cell therapy for Parkinson’s can be produced in the lab,” said Tilo Kunath of the MRC Center for Regenerative Medicine, University of Edinburgh, who was not involved in the research.

The next step will be to test the treatment in a first-in-human clinical trial, which Jun Takahashi of Kyoto University told Reuters he hoped to start by the end of 2018.

Any widespread use of the new therapy is still many years away, but the research has significantly reduced previous uncertainties about iPS-derived cell grafts.

The fact that this research uses iPS cells rather human embryonic stem cells means the treatment would be acceptable in countries such as Ireland and much of Latin America, where embryonic cells are banned.

Excitement about the promise of stem cells has led to hundreds of medical centers springing up around the world claiming to be able to repair damaged tissue in conditions such as multiple sclerosis and Parkinson’s.

While some treatments for cancer and skin grafts have been approved by regulators, many other potential therapies are only in early-stage development, prompting a warning last month by health experts about the dangers of “stem-cell tourism.”

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Change in US Policy Makes It Harder to Rebuild for Future Floods

Two weeks before Harvey’s floodwaters engulfed much of Houston, President Donald Trump quietly rolled back an order by his predecessor that would have made it easier for storm-ravaged communities to use federal emergency aid to rebuild bridges, roads and other structures so they can better withstand future disasters.

Now, with much of the nation’s fourth-largest city under water, Trump’s move has new resonance. Critics note the president’s order could force Houston and other cities to rebuild hospitals and highways in the same way and in the same flood-prone areas.

“Rebuilding while ignoring future flood events is like treating someone for lung cancer and then giving him a carton of cigarettes on the way out the door,” said Michael Gerrard, a professor of environmental and climate change law at Columbia University. “If you’re going to rebuild after a bad event, you don’t want to expose yourself to the same thing all over again.”

Trump’s action is one of several ways the president, who has called climate change a hoax, has tried to wipe away former President Barack Obama’s efforts to make the United States more resilient to threats posed by the changing climate.

Consideration of climate predictions

The order Trump revoked would have permitted the rebuilding to take into account climate scientists’ predictions of stronger storms and more frequent flooding.

Bridges and highways, for example, could be rebuilt higher, or with better drainage. The foundation of a new fire station or hospital might be elevated an extra 3 feet (1 meter).

While scientists caution against blaming specific weather events like Harvey on climate change, warmer air and warmer water linked to global warming have long been projected to make such storms wetter and more intense. Houston, for example, has experienced three floods in three years that statistically were once considered 1-in-500-year events.

The government was still in the process of implementing Obama’s 2015 order when it was rescinded. That means the old standard — rebuilding storm-ravaged facilities in the same way they had been built before — is still in place.

Trump revoked Obama’s order as part of an executive order of his own that he touted at an August 15 news conference at Trump Tower. That news conference was supposed to focus on infrastructure, but it was dominated by Trump’s comments on the previous weekend’s violence in Charlottesville, Virginia.

Trump didn’t specifically mention the revocation, but he said he was making the federal permitting process for the construction of transportation and other infrastructure projects faster and more cost-efficient without harming the environment.

“It’s going to be quick, it’s going to be a very streamlined process,” Trump said.

Asked about the revocation, the White House said in a statement that Obama’s order didn’t consider potential impacts on the economy and was “applied broadly to the whole country, leaving little room or flexibility for designers to exercise professional judgment or incorporate the particular context” of a project’s location.

Construction curbs

Obama’s now-defunct order also revamped Federal Flood Risk Management Standards, calling for tighter restrictions on new construction in flood-prone areas. Republicans, including Senator John Cornyn of Texas, opposed the measure, saying it would impede land development and economic growth.

Revoking that order was only the latest step by Trump to undo Obama’s actions on climate change.

In March, Trump rescinded a 2013 order that directed federal agencies to encourage states and local communities to build new infrastructure and facilities “smarter and stronger” in anticipation of more frequent extreme weather.

Trump revoked a 2015 Obama memo directing agencies developing national security policies to consider the potential impact of climate change.

The president also disbanded two advisory groups created by Obama: the interagency Council on Climate Preparedness and Resilience and the State, Local and Tribal Leaders Task Force on Climate Preparedness and Resilience.

Obama’s 2015 order was prompted in part by concerns raised by Colorado Governor John Hickenlooper after severe flooding in his state two years earlier. Hickenlooper was dismayed to learn that federal disaster aid rules were preventing state officials from rebuilding “better and smarter than what we had built before.”

The “requirements essentially said you had to build it back exactly the way it was, that you couldn’t take into consideration improvements in resiliency,” Hickenlooper, a Democrat, said Tuesday. “We want to be more prepared for the next event, not less prepared.”

Bud Wright, the Federal Highway Administration’s executive director during George W. Bush’s administration, said this has long been a concern of federal officials.

He recalled a South Dakota road that was “almost perpetually flooded” but was repeatedly rebuilt to the same standard using federal aid because the state didn’t have the extra money to pay for enhancements.

“It seemed a little ridiculous that we kept doing that,” said Wright, now the American Association of State Highway and Transportation Officials’ executive director.

Big federal ‘checkbook’

But Kirk Steudle, director of Michigan’s Department of Transportation, said states can build more resilient infrastructure than what they had before a disaster by using state or nonemergency federal funds to make up the cost difference.

“That makes sense, otherwise FEMA would be the big checkbook,” he said, referring to the Federal Emergency Management Agency. “Everybody would be hoping for some disaster so FEMA could come in and build them a brand-new road to the 2020 standard instead of the 1970 standard.”

Even though Obama’s order has been revoked, federal officials have some wiggle room that might allow them to rebuild to higher standards, said Jessica Grannis, who manages the adaptation program at the Georgetown Climate Center.

If local building codes in place before the storm call for new construction to be more resilient to flooding, then federal money can still be used to pay the additional costs.

For example, in Houston regulations require structures to be rebuilt 1 foot (30 centimeters) above the level designated for a 1-in-100-year storm. And in the wake of prior disasters, FEMA has moved to remap floodplains, setting the line for the 1-in-100-year flood higher than it was before.

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Dream Chaser Spacecraft in Captive-carry Test Over Desert

A test version of a spacecraft resembling a mini space shuttle was carried aloft over the Mojave Desert by a helicopter Wednesday in a precursor to a free flight in which it will be released to autonomously land on a runway as it would in a return from orbit.

 

Sierra Nevada Corp.’s Dream Chaser craft was lifted off the ground at 7:21 a.m., at NASA’s Armstrong Flight Research Center on Edwards Air Force Base, California, and was carried to the same altitude and flight conditions it will experience before release in a free flight.

 

A control team sent commands to the wingless vehicle and collected data before the helicopter brought it down at 9:02 a.m., the company said.

 

“Everything we have seen points to a successful test with useful data for the next round of testing,” director of flight operations Lee “Bru” Archambault said in a statement.

 

A second captive-carry test is scheduled this year and if it is successful, a free flight test will follow.

 

The Dream Chaser is being developed to carry cargo to and from the International Space Station without a crew aboard. The version flown Wednesday is for tests in the atmosphere. The version that will be launched into space is still in development.

 

With the addition of life-support equipment, a Dream Chaser could transport a crew of seven.

 

Last month, Sierra Nevada selected United Launch Alliance’s Atlas 5 rocket to launch the first two Dream Chaser cargo missions, which are scheduled to blast off from Cape Canaveral, Florida, in 2020 and 2021. Those missions will land at Kennedy Space Center.

 

The Dream Chaser is a type of craft known as a “lifting body” in which aerodynamic lift is generated by its shape rather than wings like those of a conventional aircraft. Tail fins angling upward at the rear of the craft provide control.

 

NASA proved the lifting body concept by flying a series of wingless aircraft at Edwards in the 1960s and ’70s.

 

The Dream Chaser is 30 feet (9 meters) long, about one quarter the length of a space shuttle.

 

Sierra Nevada is headquartered in Sparks, Nevada, and the Dream Chaser is being developed by the company’s Louisville, Colorado-based Space Systems business.

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IMF Says Transport, Food Costs Are Up in Qatar After Rift

The International Monetary Fund said Wednesday that transportation and food costs in Qatar had “edged up” because of a diplomatic rift that led four Arab countries to cut ties with the small Gulf state.

An IMF team visited the capital, Doha, this week, saying in a statement that Qatar’s government was able to soften the immediate impact of trade disruptions, but that some costs had gone up as a result of delays caused by rerouting trade. Non-oil growth is projected to shrink to 4.6 percent this year, down 1 percentage point.

In June, Saudi Arabia, the United Arab Emirates, Bahrain and Egypt cut diplomatic and transport links with Qatar. Saudi Arabia also sealed Qatar’s only land border, a major conduit for imports.

Qatar turned to other exporters like Turkey, Iran and Morocco to fill gaps in its food imports and the construction material needed to build infrastructure for soccer’s World Cup in 2022, set to take place there. Qatar also rerouted its shipments through ports in Oman after the UAE blocked Qatar-bound shipments from using its national waters.

The IMF said Qatar’s banking sector remained sound and that the impact of the severed ties was mitigated by liquidity injections by the Qatar Central Bank and increased public sector deposits. The international lender said Qatar was prepared for any withdrawal of nonresident deposits.

The four countries accused Qatar of sponsoring terrorism and backing extremist groups. Qatar denied the accusations and said the moves were aimed at pressuring the country to fall in lockstep with policies formulated in Riyadh and Abu Dhabi.

The IMF warned the rift could have a wider impact across the Gulf Cooperation Council, which consists of Qatar, Saudi Arabia, the UAE, Bahrain, Kuwait and Oman.

“Over the longer term, the diplomatic rift could weaken confidence and reduce investment and growth, both in Qatar and possibly in other GCC countries as well,” the statement said.

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Matt Damon Goes Mini in Venice Opener ‘Downsizing’

Downsizing has generated jumbo-sized buzz at the Venice Film Festival — not least as viewers debate how to describe it.

Is it a science fiction film, a romantic comedy, a political parable, an apocalyptic thriller? Alexander Payne’s movie mixes all those elements in its story of a man, played by Matt Damon, who tries to solve his problems by shrinking himself.

Damon and co-stars Kristen Wiig and Hong Chau joined Payne on the red carpet for the film’s Venice premiere Wednesday — the first of 11 days of galas that will bring stars including George Clooney and Jennifer Lawrence to the canal-crossed Italian city.

The Venice opening-night slot has become coveted by filmmakers hoping to make a splash come awards season. Several recent Venice openers, including Gravity and La La Land, have gone on to win multiple Academy Awards.

Downsizing has ingredients that could help it strike a similar chord with audiences and awards voters: a likable, bankable star in Damon; a strong supporting cast that includes Wiig and Christophe Waltz; and an imaginative story laced with compassion and humor.

Payne says despite its sci-fi premise and international canvas, Downsizing is not so different to the films he’s best known for — funny-sad stories of middle-aged or Midwestern strugglers such as About Schmidt, Sideways and Nebraska.

 “It has the same sense of humor and basically the same tone,” Payne told reporters in Venice on Wednesday.

The movie applies Payne’s wry eye for human foibles to a plot that explores the power and limits of science and the threat of environmental catastrophe.

The script by Payne and Jim Taylor opens with a Norwegian scientist making a breakthrough he thinks will save humanity: a technique that can shrink people to 5 inches (12 centimeters) tall. That means they use a tiny fraction of the resources they once did — and need to pay less, allowing people of modest means to grow instantly rich by becoming small.

The movie has fun imagining what the miniaturized world would be like, as Damon goes to live in a luxury micro-city, a sort of retirement community for the tiny.

Then it takes a serious turn to ask whether science could be humanity’s salvation, or whether stubbornly fallible human nature is likely to be our species’ undoing.

Along the way, a movie that started in the familiar Payne territory of Omaha, Nebraska, takes viewers all the way to an underground bunker in a Norwegian fjord.

Many will find the journey unexpected, but reviewers in Venice were mostly happy to be swept along for the ride. The Guardian called the film a “spry, nuanced, winningly digressive movie,” while the Hollywood Reporter said it was “captivating, funny” and “deeply humane.”

Ultimately, the film rests on Payne’s knack for depicting human relationships. Damon’s Paul becomes friends with a louche European neighbor, played by Waltz, and develops feelings for Ngoc Lan, a former Vietnamese political prisoner working as a house cleaner.

Actress Hong Chau (Treme, Inherent Vice) is already being talked of as a potential awards nominee for her performance as the spirited, complex character.

“This is a character that is normally in the background, that is low-status character in the culture, and not one that you typically see in the forefront of a story,” she said.

Downsizing is the latest ordinary-Joe role for Damon, who exudes a likable everyman-under-duress quality whether he’s action hero Jason Bourne or a stranded astronaut in The Martian.

Damon said he thinks movies “are the greatest tool for empathy that we have.”

“What I love about this — what I love about a lot of these stories that I get to help tell — is it shows a relatable character whose life is different from our own but who we find common cause with,” he said. “This is a beautiful and optimistic movie. A journalist said to me, which I thought was really great: `This is Alexander’s most optimistic movie and it has the apocalypse in it.”‘

The film has been in the works for a decade, but in an AP interview, Damon said its environmental theme felt “torn from the headlines.”

“Though the [U.S.] administration wouldn’t say that,” he added. “They’re not acknowledging climate change as a reality.”

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Famed T. rex ‘Sue’ Will Get New Look at Chicago’s Field Museum

The world’s biggest T. rex is getting ready for a cutting-edge makeover.

The Field Museum in Chicago said Wednesday that it would take down and remount the 40½-foot-long (12.3-meter) Tyrannosaurus nicknamed Sue, perhaps the world’s most famous dinosaur fossil, in a way that embodies the latest understanding of this ferocious Cretaceous Period predator.

The big T. rex will move to a new exhibition space in the museum, while a cast of the skeleton of the largest-known dinosaur, Patagotitan mayorum, will take the spot Sue now occupies in the museum’s Stanley Field Hall.

Patagotitan, a long-necked, four-legged plant-eater that was 122 feet (37.2 meters) long and weighed 70 tons, lived in Argentina 100 million years ago, more than 30 million years before T. rex stalked western North America. The biggest land animal on record, it was a member of a dinosaur group called titanosaurs.

The museum next spring will unveil the fiberglass Patagotitan skeleton, which is being cast from fossils of seven Patagotitan individuals, and for two years will display some of the genuine fossils, including an 8-foot (2.4-meter) thighbone.

Named for the woman who discovered the fossils in South Dakota in 1990, Sue is the largest, most complete and best-preserved Tyrannosaurus rex ever unearthed. The museum bought the fossils at auction for $8.4 million.

Sue will be taken down in February and put up again with noteworthy changes in anatomy and stance in its new exhibition hall in spring 2019, museum scientists said.

“We are making several adjustments to the skeleton to reflect new and improved knowledge,” said paleontologist Pete Makovicky, the museum’s associate curator of dinosaurs.

The most striking change, Makovicky said, will be the addition of gastralia, bones resembling an additional set of ribs spanning the belly that may have provided structural support to help the dinosaur breathe. Adding these bones will illustrate just how massive Sue was and that it boasted a bulging belly, he added.

The scientists concluded that the bone mounted as Sue’s wishbone was misidentified in 2000, and they will replace it with the dinosaur’s actual wishbone, or furcula, the fused collarbones typical of meat-eating dinosaurs and their evolutionary descendants, the birds.

They also will adjust the ribs to produce a slimmer, less barrel-shaped chest and arrange the right leg so Sue is not crouching as much.

“Often when you do something as expensive as mounting a vertebrate fossil skeleton for display, you only get one shot at it. I’m happy we’re going to fix and update this incredible fossil,” said paleontologist Bill Simpson, who heads the museum’s geological collections.

Lifespan and bite force

Makovicky noted the accumulation of knowledge about T. rex and its cousins since 2000.

“We now know more about tyrannosaur lifespans — around 30 years; how they grew — very fast as teenagers; and using computer models of Sue, we revised their body mass upward to 9 or more tons, from 5 to 7 tons,” Makovicky said.

Ongoing research is examining the molecular composition of cartilage preserved in T. rex bones, and recent studies have shown it possessed the most powerful bite of any land animal ever, Makovicky added.

When the Patagotitan skeleton is mounted, visitors will be able to walk underneath it and touch it. Its head will reach the museum’s second-floor balcony nearly 30 feet (9 meters) up.

Another Patagotitan skeleton is displayed at the American Museum of Natural History in New York.

The museum said a $16.5 million gift from the Kenneth C. Griffin Charitable Fund, established by the founder and chief executive of hedge fund firm Citadel LLC, enabled it to carry out Sue’s makeover and add the Patagotitan. The changes coincide with the museum’s 125th anniversary in 2018.

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Waiting, Watching: Business Owners Worry About Harvey Damage

With the animals sent to safety before Harvey hit, the owners of CityVet in Houston kept watch on their empty practice by security camera, hoping not to see floodwaters rush in.

But they lost the video stream Monday morning, apparently when power to the building near Houston’s Galleria failed. So, it was impossible to assess if any damage was occurring, said Paul Kline, a veterinarian based in and watching from Dallas. To his relief, the video came back Tuesday and “we could see cars going by on the street outside — a good sign,” Kline said. By Wednesday, with the rains gone, he could see the practice had escaped the flooding in the area.

Plenty of small-business owners spent a long five days, waiting to see if the rainfall that totaled more than 50 inches in some places would flood their businesses. Harvey’s winds and rains damaged or destroyed many small businesses in the storm’s path along the Gulf Coast.

It was a tornado spawned by Harvey that destroyed the office of Kenneth Bryant’s used-car dealership in Katy, Texas, just west of Houston. The winds Saturday morning picked up the office and slammed it into the building next door.

“I lost everything in there: titles to vehicles, keys, paperwork, computers,” said Bryant, whose business was not insured. Two of the 10 cars in his inventory were destroyed.

There was more bad news Wednesday: The remaining cars had been flooded. Bryant won’t know how severely they were damaged until he is able to unlock them.

“Where do we go from here? I don’t know. It’s going to be such a long road ahead,” Bryant said.

Lost sales, revenue, profits

For many companies, damage to their premises was just the start. Some lost inventory that would cost them future sales. Workers were stranded or dealing with the devastation of their homes. Companies that couldn’t operate were losing revenue and profits every day.

Fiyyaz Pirani estimates that his Houston-based company, Medology, lost $100,000 in new business. It’s been operating with six staffers instead of its usual 60 since the storm began, and accommodating only existing customers.

“We had a couple of employees who sustained a lot of damage to their homes, and some people are in shelters,” he said.

The company, which helps patients get low-cost lab tests and other services, moved back to its regular location Tuesday from temporary quarters, with generator power but no air conditioning. Staffers were working around some puddles of water at their top-floor office.

Eleanor Rem had several inches of water in her Houston home, which also houses her business. Rem, who helps children with dyslexia learn to read, opted not to try what might have been a difficult evacuation with an 88-year-old relative.

The rains that flooded her street, backyard and driveway on Monday began creeping into her home. She and her husband got their first-floor furniture upstairs, but the carpet was soaked. Rem said she was constantly checking to see how bad the damage was.

“We’re pretty exhausted. You’re kind of nervous to go to sleep,” she said Wednesday. She expects she won’t be able to work for several weeks, in part because her students may not be able to get to her home.

‘Cross your fingers and hope for the best’

Other business owners who tried to keep an eye on their companies by watching the video from surveillance cameras ran into the same problems as the veterinary practice.

With all three of Clint Hall’s Beef Jerky Outlet stores near Houston in danger of flooding, he watched from his home in Cypress. The Galveston Island store got a foot of water as the rains continued Monday and Tuesday, but he could see the Tomball location was safe. The League City shop lost power and its cameras Saturday, so Hall had to rely on the owner of a nearby pizzeria for periodic updates. When the rains finally stopped, it had suffered one minor leak.

It was a hard five days. As Hall watched his cameras, he said, “we’re doing as well as we can.” He planned to open at least two of the stores Wednesday.

Lindsey Rose King spent five days not knowing whether the inventory for Mostess, her home decor gift box company, was safe. The warehouse where it’s all stored — cloth napkins and tablecloths, bottles of spices and cocktail mixes and other items — is in the Galleria section. The warehouse owners had to evacuate their home and couldn’t monitor the situation.

“It’s nerve-wracking. If that inventory gets wet, that’s my whole business,” King said. But Wednesday morning, the email came: Although the building did get some water, King’s merchandise was safe and dry.

Merin Guthrie worried about the possibility that water had seeped into the old loft building near downtown Houston that houses Kit, her clothing design business. Her studio is on the second floor, but friends in similar buildings said they had water coming in through their windows. Even if her fabric, samples and sewing equipment were dry, there was a threat of mold.

She got into the building Wednesday morning, found that water had indeed gotten in, but that her supplies and equipment were OK.

“You have to cross your fingers and hope for the best,” Guthrie said.

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US Clears First ‘Living Drug’ for Tough Type of Leukemia

Opening a new era in cancer care, the Food and Drug Administration on Wednesday approved the first treatment that genetically engineers patients’ own blood cells into an army of assassins to seek and destroy childhood leukemia.

The CAR-T cell treatment developed by Novartis Pharmaceuticals and the University of Pennsylvania is the first type of gene therapy to hit the U.S. market — and one in a powerful but expensive wave of custom-made “living drugs” being tested against blood cancers and some other tumors, too.

FDA called the approval historic.

“This is a brand-new way of treating cancer,” said Dr. Stephan Grupp of Children’s Hospital of Philadelphia, who treated the first child with CAR-T cell therapy — a girl who’d been near death but now is cancer-free for five years and counting. “That’s enormously exciting.”

Novartis said it would charge $475,000 for the treatment, made from scratch for every patient. But, the company said there would be no charge if the patient didn’t show a response within a month.

CAR-T treatment uses gene therapy techniques not to fix disease-causing genes but to turbocharge T cells, immune system soldiers that cancer too often can evade. Researchers filter those cells from a patient’s blood, reprogram them to harbor a “chimeric antigen receptor” that zeroes in on cancer, and grow hundreds of millions of copies. Returned to the patient, the revved-up cells can continue multiplying to fight disease for months or years.

Different path

It’s a completely different way to harness the immune system than popular immunotherapy drugs called “checkpoint inhibitors” that treat a variety of cancers by helping the body’s natural T cells better spot tumors. CAR-T cell therapy gives patients stronger T cells to do that job.

“We’re entering a new frontier in medical innovation with the ability to reprogram a patient’s own cells to attack a deadly cancer,” said FDA Commissioner Scott Gottlieb.

This first use of CAR-T therapy is aimed at patients desperately ill with a common pediatric cancer — acute lymphoblastic leukemia, or ALL — that strikes more than 3,000 children and young adults in the U.S. each year. While most survive, about 15 percent relapse despite today’s best treatments, and their prognosis is bleak.

In a key study of 63 advanced patients, 83 percent went into remission. It’s important to note, however, that it’s not clear how long that benefit lasts: Some patients did relapse months later, and the others still are being tracked to see how they fare over the long term.

Still, “a far higher percentage of patients go into remission with this therapy than anything else we’ve seen to date with relapsed leukemia,” said Dr. Ted Laetsch of the University of Texas Southwestern Medical Center, one of the study sites. “I wouldn’t say we know for sure how many will be cured yet by this therapy. There certainly is a hope” that some will be.

Most patients suffered side effects that can be grueling, even life-threatening. An immune overreaction called “cytokine release syndrome” can trigger high fevers, plummeting blood pressure and in severe cases organ damage, requiring special care to tamp down those symptoms without blocking the cancer attack. Also Wednesday, the FDA designated a treatment for those side effects.

“This is remarkable technology,” said Dr. Mikkael Sekeres of the American Society of Hematology. But, he cautioned, “it isn’t a panacea.”

Possible resistance

Among concerns, sometimes leukemia can develop resistance, and sometimes patients worsen while waiting for their new cells, said Sekeres, who directs the Cleveland Clinic’s leukemia program and wasn’t involved with CAR-T testing.

“Unfortunately, leukemia grows so rapidly that it can evade even the smartest of our technologies,” he added.

For some patients, the new CAR-T therapy might replace bone marrow transplants that cost more than $500,000, noted Grupp, who led the Novartis study.

“I don’t want to be an apologist for high drug prices in the U.S.,” Grupp stressed. But if it’s the last treatment they need, “that’s a really significant one-time investment in their wellness, especially in kids who have a whole lifetime ahead of them.”

Initially, Novartis’ CAR-T version — to be sold under the brand name Kymriah (kihm-REYE’-eh) — will be available only through certain medical centers specially trained to handle the sophisticated therapy and its side effects. Patients’ collected immune cells will be frozen and shipped to a Novartis factory in New Jersey that creates each dose, a process the company says should take about three weeks.

While this first use of CAR-T therapy is aimed at only a few hundred U.S. patients a year — relapsed ALL patients up to age 25 — it’s being tested as a treatment for thousands more. Kite Pharma’s similar CAR-T brand, developed by the National Cancer Institute, is expected to win approval later this year to treat aggressive lymphoma, and Juno Therapeutics and other companies are studying their own versions against blood cancers including multiple myeloma.

Scientists around the country also are trying to make CAR-T therapies that could fight more common solid tumors such as brain, breast or pancreatic cancers — a harder next step.

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Jordan, Iraq Reopen Main Border Crossing on Baghdad to Amman Highway

Tureibil, Iraq’s main international border crossing with Jordan and a key trade route, officially reopened Wednesday after being officially closed for three years. Privately-owned U.S. security firms, along with Iraqi ground and air forces, will be responsible for safety along the 500-kilometer route from Baghdad to Amman, which goes through Iraq’s Anbar province.

Iraqi forces have cleared areas near the highway of Islamic State militants in recent months, and parts of the route, including a number of bridges and overpasses, were rebuilt or repaired.

The Iraqi parliament agreed to allow U.S. security firms to oversee the highway, after a long and heated debate.

Iraqi Prime Minister Haidar al-Abadi indicated in a tweet Wednesday that he was “pleased by the reopening of the Iraq-Jordan border crossing,” adding that it will “increase bilateral relations considerably.”

The deputy head of the Anbar provincial council, Falah al-Aissawi, told al-Hurra TV recently that the provincial government was doing its utmost to reopen the key highway.

He says that Anbar province is using part of its budget to reopen the highway and the crossing with Jordan, which is a lifeline for both Anbar and the country, and that its reopening to traffic will give a boost to the economy.

Iraqi Interior Minister Qassem al-Araji inspected the highway and the border crossing several days ago, noting that the security situation appeared to be good.

The interior minister says he has inspected all the key infrastructure along the route and that Iraq was intent on reopening all its border crossings. He says the Tureibil crossing is vital to Iraq’s economy.

Hilal Khashan, who teaches political science at the American University of Beirut, tells VOA that the reopening of the Iraqi border with Jordan was yet another step in the ongoing collapse of the Islamic State group.

“It’s clear that IS is being defeated and it is in full retreat on all fronts. This move points in the direction of increasing security in both Iraq and Jordan,” said Khashan.

Khashan also thinks that Jordan agreed to reopen its border crossing with Iraq “in conjunction with both the U.S. and Saudi Arabia,” and that the move “marks a significant improvement of ties between Iraq, Jordan, Saudi Arabia, and [possibly] Iran.”

Iraq and Saudi Arabia recently reopened their land border, which had been closed since 1990.

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Harvey May Cut US Economic Growth as It Boosts Gasoline Prices

Energy companies, homeowners, and others are calculating the cost of Hurricane Harvey, which has already boosted gasoline prices and may slow the growth of the huge U.S. economy.

Gasoline prices surged to a two-year high recently as record floods forced refineries and other oil industry operations to close in Texas and elsewhere.

Oil industry analysts say nearly one-quarter of the U.S. refining capacity is shut, which prompted worries about future supplies and rising prices. Crude oil prices sagged because closed refineries mean lower demand for this raw material. Some analysts predicted the price hikes would be temporary, but cautioned it is not yet clear how much damage has been done to some of the world’s largest refineries.

The total cost of the disaster is unclear because floodwaters are still rising and officials have been focused on rescuing people not assessing damage to facilities. Preliminary estimates vary widely, and run into the tens of billions of dollars.

Some of that cost comes from closed airports that normally handle 1,600 or more flights per day. Other losses come from the closed shipping facilities that normally see thousands of containers and considerable oil that normally moves through Houston and nearby areas each day.

Data analysis expert Josh Green of Pajjiva said there is likely to be a major impact on the local community, but shippers will find alternate ports for cargos, which will limit the damage to the national economy.

Billionaire Warren Buffett, one of the world’s most astute and successful investors, told CNBC, a financial news channel, the storm has caused serious destruction, but the toll is probably less than one percent of the U.S. GDP.

Wednesday, the Commerce Department said U.S. economic growth had sped up to a three percent annual rate in the second quarter (April, May and June) which is faster than first estimated.

Analysts at Macroeconomic Advisers say Harvey could cut anywhere from three-tenths of a percent to more than one percent from growth in the third quarter (July, August, September).

IHS Markit Chief Economist Nariman Behravesh said previous storms have hurt short-term growth, which has eventually been offset by an economic boost from reconstruction activity. He said the many uncertainties about the extent of damage will make economic estimates “volatile” for the last six months of this year.

Cornell University business professor Steven Kyle told VOA some economic tools do a poor job of measuring the impact of disasters because they count the reconstruction work as an economic gain, but do not have an accurate way to measure the cost of lost bridges, homes and workplaces.

Kyle also said the impact of the storm is not going to show up in unemployment data till the end of September.

The newest U.S. jobless rate will be published by government experts this Friday, but that information was gathered before the storm hit. Economists predict the jobless rate for August will be a very low, at 4.3 percent.

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Alexa, Cortana Talk to Each Other in Amazon-Microsoft Deal

Microsoft and Amazon are pairing their voice assistants together in a collaboration announced Wednesday.

Both companies say later this fall, users will be able to access Alexa using Cortana on Windows 10 computers and on Android and Apple devices. They’ll also be able to access Cortana on Alexa-enabled devices such as the Amazon Echo.

Microsoft says the tie-up will allow Alexa customers to get access to Cortana features such as for booking meetings or accessing work calendars. Cortana users, in turn, can ask Alexa to switch on smart home devices or shop on Amazon’s website.

The use of voice assistants is growing. Google and Amazon already have smart speakers on the market. Apple has HomePod coming with its Siri assistant, while Samsung plans one with Microsoft’s Cortana.

Amazon has little to lose from the partnership, and Microsoft’s Cortana — which has been largely limited to laptops — might get discovered by more users because of it, said Carolina Milanesi, a mobile technology analyst at Creative Strategies.

“Cortana might get a little bit more out of it because it gets Cortana out of the PC,” she said. “For Cortana to really get to be more important, it needs to be consistently used every day for different tasks.”

Milanesi said that for Amazon especially, which wants more people to consider Alexa as their first choice, the partnership also might be designed to send a message to customers and rivals.

“They both get something out of it, which is mainly showing Apple and Google that they’re willing to work together to get stronger,” Milanesi said.

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Dubai Street Cleaners Beat the Heat With ‘Cooling Collars’

Street cleaners in Dubai are wearing new “cooling collars” to prevent heatstroke as they work in rising Gulf temperatures that can hit 45 degrees C (113 degrees F), Dubai said Wednesday.

The Middle East emirate issued orange fabric collars containing a chilled gel, similar to the cold compresses used for injuries, to 4,000 cleaners.

“This type of cooling material [can]… protect the body from high temperature so that the worker is not subject to heat exhaustion,” Abdulmajeed Saifaie, director of the waste department, said in a statement.

Projections show the Gulf region will be the world’s hottest region by 2100 as a result of climate change.

With small, wealthy populations and minimal domestic food production, oil-rich states in the Gulf can respond better to rising heat than poorer countries in South Asia, experts say.

The collars can work for up to six hours, after which they must be put in a fridge to refreeze the gels.

Temperatures in the Gulf will become “intolerable” for humans by the end of the century if climate change is not addressed, a 2015 Nature Climate Change study showed.

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US Hosts World Cup Qualifier in New York Area for 1st Time

The U.S. is playing a World Cup qualifier in the New York metropolitan area for the first time, a critical match against Costa Rica on Friday night at Red Bull Arena in Harrison, New Jersey.

The Americans have played plenty of matches in and near the Big Apple, mostly in the CONCACAF Gold Cup and exhibition games. Until now, the closest to New York a qualifier has been played was in 1989, a 2-1 win over Guatemala at Veterans Stadium in New Britain, Connecticut.

“This was a pipe dream, this stadium in Harrison,” said goalkeeper Tim Howard, who played for the New York/New Jersey MetroStars when the team was based at Giants Stadium in East Rutherford. “For it to be there and to actually be playing games, you know, there’s no crowd like playing in front of your home crowd for me.”

Howard spoke Tuesday during a news conference in Manhattan, joined by coach Bruce Arena, captain Michael Bradley and teenage star midfielder Christian Pulisic.

After the U.S. opened the final round of the North and Central American and Caribbean region with losses to Mexico and Costa Rica, the U.S. Soccer Federation brought back Arena to replace coach Jurgen Klinsmann. The U.S. has recovered and is in third place with eight points, trailing Mexico (14) and Costa Rica (11). Panama (seven), Honduras (five) and Trinidad and Tobago (three) follow.

The top three nations qualify, and the fourth-place team advances to a playoff against Asia’s No. 5 nation.

Perhaps no one understands the role fan support can play in an outcome more than Arena, a member of the U.S. National Soccer Hall of Fame. The U.S. had a 16-year home unbeaten streak in qualifying going into a match against Honduras at RFK Stadium in Washington, D.C., on Sept. 1, 2001. The majority of the sellout crowd of 54,282 backed Honduras, which won 3-2.

“Only in America, I guess, we’re fighting for a home-field advantage,” Arena, who was born in Brooklyn and raised in Long Island, said at the time.

Costa Rica played a Gold Cup match at Harrison in July, but Arena expects a different crowd.

“We’re playing at home and I don’t care what anyone says. We have a home-field advantage,” Arena said. “My experiences in the short time that I’ve been here back with the U.S. team is that we have great support and I really believe that we’ll have great support on Friday, and hopefully the fact that Costa Rica played here in the Gold Cup is not going be a factor.”

At a venue with a 25,000 capacity that was built for Major League Soccer, the USSF and Red Bulls can control ticket allocation with pre-sales to Red Bulls season-ticket holders and national team regulars.

“We understand the challenges of playing at home versus going on the road in CONCACAF and we’re willing to do whatever it takes to make sure that in five or six weeks’ time we’ve punched our ticket to Russia,” Bradley said. “It’s on us to make sure that we can finish the job and allow ourselves the chance to look forward to playing at a World Cup next summer.”

The U.S. plays Honduras at San Pedro Sula on Sept. 5, and then closes the hexagonal against Panama on Oct. 6 at Orlando, Florida, and at Trinidad four days later.

“All the work that we’ve put in this year was for these next four games, to make sure that we can find the right ways in the biggest moments when the lights come on brightest to make sure that we get the job done,” Bradley said.

Reality check

U.S. players also have their minds on teammates and their families affected by Hurricane Harvey.

“I’ve heard DaMarcus (Beasley) speak of it. I haven’t yet had the chance yet to talk with Clint (Dempsey),” Arena said. “Hopefully his family’s safe. I know they’re in east Texas. I know it’s a tough week for them. I know for DaMarcus in particular it’s been very challenging. For him personally, for his friends and family ties to the Houston area. It’s difficult but all we can do is hope that the conditions improve in the Houston area and that everyone is safe.”

Added Bradley: “Some of the images and videos that have come out of Texas have been heartbreaking, and for all of us now as human beings, as fellow Americans, to find the right ways to show support and help that part of the country as they find the right ways to move on from this. That’s very important and obviously in our own very little way playing and representing the country in a really strong and proud way on Friday night is a little part of that.”

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Study: Cities and Companies Team Up to Tackle Urban Water Crises

With rising urban populations and ever scarcer water supplies, cities and companies are teaming up to invest billions of dollars in water management projects, a report said on Tuesday.

Around two thirds of cities from London to Los Angeles are working with the private sector to address water and climate change stresses with 80 cities seeking $9.5 billion of investment for water projects, according to a report by the Carbon Disclosure Project (CDP), a non-profit environmental research group.

Water investment opportunities are greatest in Latin America, with Quito in Ecuador seeking $800 million to manage its water supply, including building three hydropower stations and cleaning up its contaminated rivers and streams.

City in India prepares for future

The cities most concerned about their water supply lie in Asia and the Pacific, the report found, with serious risks also identified in Africa and Latin America.

The key issues for cities include declining water quality, water shortages and flooding.

The Indian city of Chennai faced extreme floods in 2015 which killed hundreds and left survivors without access to clean water, while businesses were also severely disrupted.

The city is now investing in boosting its resilience to future water crises, with water conservation education, building a storm water management system and new infrastructure.

“We are seeing critical shifts in leadership from cities and companies in response to the very real threat of flooding, for example, to local economies,” said Morgan Gillespy, head of CDP’s Water Program.

Climate change is another underlying threat to all cities with an increase in extreme weather events from droughts to floods, with cities in North America more concerned than those in Europe, the report found.

Tropical Storm Harvey, pounding the U.S. Gulf Coast, has killed at least eight people, led to mass evacuations and paralyzed Houston, the fourth most-populous U.S. city.

The storm is most likely linked to climate change, said the U.N. weather agency.

Companies are also concerned about the effects of climate change on water supplies, with $14 billion of water impacts such as loss of production reported by companies last year, the report found.

UN predicts global water shortfall

The United Nations predicts a 40 percent shortfall in global water supply by 2030, while global demand is set to increase by 55 percent due to growing domestic use, manufacturing and electricity generation.

“From our work with cities around the world, water has consistently come up as a key resilience challenge,” said Claire Bonham-Carter, Principal and City Resilience Lead at AECOM, a global infrastructure firm and partner on the report.

“Many of them, regardless of size, from Mexico City, Mexico to Berkeley, California, are addressing both long-term water supply issues as well as chronic urban flooding.”

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Peru Opposition Leader Investigated in Connection With Odebrecht

The Peruvian attorney general’s office has opened a criminal probe into opposition leader Keiko Fujimori for allegedly laundering money for scandal-plagued Brazilian builder Odebrecht, Fujimori’s attorney said on Tuesday.

The twice-defeated right-wing presidential candidate and eldest daughter of Peru’s imprisoned former leader Alberto Fujimori denied that she or her political party ever took money from Odebrecht.

“I’m certain the investigation will confirm that Odebrecht did not give us any money,” Fujimori said on Twitter. “I’ve always collaborated with all investigations and this will not be an exception.”

Fujimori’s lawyer, Edward Garcia, told Reuters the preliminary probe was opened in connection with notes that mention Fujimori by name that were taken by Odebrecht’s jailed former chief executive, Marcelo Odebrecht.

The attorney general’s office, which declined to comment, said on Monday it had received the contents of notes made on the cellphone of Odebrecht, but did not detail them.

Fujimori is already the subject of a money-laundering investigation related to 2016 campaign donations, but a probe in connection with Odebrecht might do more to hurt support for her and her Popular Force party, which controls a majority of seats in Congress.

Odebrecht is at the center of Latin America’s biggest corruption scandal and is reviled by many in Peru since admitting late last year to having bribed local officials over a decade-long period.

News website IDL Reporteros has published what it says are  notes taken by Odebrecht and confiscated by Brazilian authorities that include the phrase: “Raise Keiko to 500 and pay her a visit.”

Prosecutor German Juarez will lead the investigation into Fujimori, Garcia said.

Juarez recently persuaded local courts to jail former President Ollanta Humala for up to 18 months before trial while he is investigated for accusations of taking undeclared campaign donations from Odebrecht.

Humala narrowly defeated Fujimori during her first presidential bid in 2011. He is now sharing a prison with her father, who is serving a 25-year sentence for human rights violations and graft.

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Harvey’s Floods Scatter Cattle in Texas, Swamp Cotton Fields

South Texas ranchers are scrambling to relocate cattle from massive flooding spawned by Tropical Storm Harvey, with many hauling livestock up to the north of the state while others rush to move the animals to higher ground nearby.

About 1.2 million cattle are located in a 54-county disaster area drenched by Harvey, which made landfall as a hurricane last weekend. With more torrential rain in the forecast, ranchers are expressing worry that some animals could perish despite efforts to save them.

State is top producer of cattle, cotton   

Texas leads U.S. states in cattle and cotton production. An estimated $150 million worth of cotton has been lost as the storms ripped the bolls off plants and left white fiber strewn across fields.

Texas Gulf Coast export terminals that handle about a quarter of U.S. wheat exports also remained shuttered.

Of immediate concern to ranchers were cattle stranded by high water infested with venomous snakes, fire ants and alligators, said Hollis “Peanut” Gilfillian, a cattle rancher in Winnie, Texas, about 60 miles (96 km) east of hard-hit Houston.

“We’re in gator country … period,” said Gilfillian, adding that nearly every pond on the ranches in his area contain alligators.

“It’s not unusual to see an alligator in my backyard or road ditch,” he said, but added, “There’s plenty other animals that they (alligators) would much rather eat, such as fish, as opposed to trying to go after cattle.”

Ranchers had tried to prepare for the storm last week by moving cattle to the nearest hills or trucking them to safety in the north of the state, cattle industry groups said.

Chuck Kiker, who raises cattle on his farm near Beaumont, about 60 miles (96 km) northeast of Houston, opted to leave his animals in place but was caught off guard by the storm’s severity.

“You can’t move animals at this point, so you’re kind of stuck because of high water everywhere. There’s really no place to move them,” he said.

Disaster area declared

Texas Governor Greg Abbott has declared 54 counties a disaster area. About 27 percent of the state’s 4.46 million-head beef cow herd is in those 54 counties, according to Texas A&M University livestock economist David Anderson.

“Given that it’s August, I’m not sure that we would’ve seen a lot of the calves already sold. So you’ve a lot of young calves out there too that are in that disaster area,” Anderson said.

Grain terminals closed

Longer-term concerns for the cattle include foot rot from standing in water or muddy fields for long periods and the risk of disease from mosquitoes.

Heavy rains and flooding closed bulk grain terminals along the Texas Gulf Coast owned by major exporters including Archer Daniels Midland and Cargill, although the companies say the facilities were not severely damaged.

BNSF Railway and Union Pacific suspended service to the flood-ravaged region, depriving exporters of a fresh supply of grain. The U.S. Coast Guard closed Texas Gulf ports including Houston, Galveston and Corpus Christi.

“With additional flooding likely during the next few days, normal train flows in the area may not resume for an extended period,” BNSF said in a customer service advisory.

Cotton blown away

On cotton farms, more than 300,000 bales have likely been lost, between cotton yet to be harvested and bales sitting on fields awaiting ginning, according to John Robinson, an agricultural economist at Texas A&M University.

The loss, though a small part of the total U.S. cotton crop of about 20 million bales a year, was devastating for individual farmers.

“The cotton that was where the hurricane hit was affected by the winds, it was blown right off the plant. Some of those fields are obliterated,” Robinson said.

“Some of the cotton will still be on the plant but strung out like someone papered your field with toilet paper,” he said.

Record crop lost

South Texas and Coastal Bend cotton farmers were expecting a record crop this year. Thirteen of the counties in the disaster area are major cotton producers.

“The South Texas Cotton and Grain Association has preliminary crop losses projected at $150 million. That’s just devastating to all of farmers down there,” Texas Agriculture Commissioner Sid Miller said in a statement.

Monday’s Intercontinental Commodity Exchange benchmark cotton price spiked 2.5 percent as a portion of the unharvested crop in Texas was destroyed or damaged by rain and high winds, traders said.

“The cooperative’s growers still have a lot of cotton in the field, maybe like 50 percent still out there. A lot of that will be lost because of the wind and rain,” said Jimmy Roppolo, general manager of United Agricultural Cooperative Inc in El Campo, Texas.

“It was the best cotton crop we ever raised. We really needed it this year to make up for other years,” Roppolo said.

 

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World’s Biggest Drone Drug Deliveries Take Off in Tanzania

Tanzania is set to launch the world’s largest drone delivery network in January, with drones parachuting blood and medicines out of the skies to save lives.

California’s Zipline will make 2,000 deliveries a day to more than 1,000 health facilities across the east African country, including blood, vaccines and malaria and AIDS drugs, following the success of a smaller project in nearby Rwanda.

“It’s the right move,” Lilian Mvule, 51, said by phone, recalling how her granddaughter died from malaria two years ago.

“She needed urgent blood transfusion from a group O, which was not available,” she told the Thomson Reuters Foundation.

Malaria is a major killer in Tanzania, and children under age 5 often need blood transfusions when they develop malaria-induced anemia. If supplies are out of stock, as is often the case with rare blood types, they can die.

Tanzania is larger than Nigeria and four times the size of the United Kingdom, making it hard for the cash-strapped government to ensure all of its 5,000-plus clinics are fully stocked, particularly in remote rural areas.

The drones fly at 100 kph (62 mph), much faster than traveling by road. Small packages are dropped from the sky using a biodegradable parachute.

The government also hopes to save the lives of thousands of women who die from profuse bleeding after giving birth.

Tanzania has one of the world’s worst maternal mortality rates, with 556 deaths per 100,000 deliveries, government data show.

“It’s a problem we can help solve with on-demand drone delivery,” Zipline’s chief executive, Keller Rinaudo, said in a statement. “African nations are showing the world how it’s done.”

Companies in the United States and elsewhere are keen to use drones to cut delivery times and costs, but there are hurdles ranging from the risk of collisions with airplanes to ensuring battery safety and longevity.

The drones will cut the drug delivery bill for Tanzania’s capital, Dodoma, one of two regions where the project will first roll out, by $58,000 a year, according to Britain’s Department for International Development, one of the project’s backers.

The initiative could also ease tensions between frustrated patients and health workers.

“We always accuse nurses of stealing drugs,” said Angela Kitebi, who lives 40 kilometers east of Dodoma. “We don’t realize that the drugs are not getting here on time due to bad roads.”

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Tragic Child Deaths Spur Indian Schoolgirl to Raise Funds for Oxygen

A 15-year-old schoolgirl in northern India has launched a charity to provide oxygen to impoverished patients after 63 people, nearly half of them children, died due to a lack of oxygen at the main government hospital in her home town.

The patients died from encephalitis, a disease which causes brain inflammation, after the hospital in Gorakhpur ran out of oxygen due to unpaid bills, triggering outrage over India’s poorly managed state-run healthcare system.

“This tragedy was something that could have been prevented,” said teenager Khushi Chandra, who set up Oxygen Gorakhpur, to raise funds for oxygen in hospitals.

“This is very personal for me as it happened right at my doorstep… No child can be denied the right to life, and in this case the right to breathe,” she said in a statement.

“As an accountable citizen of my city and my country, I feel responsible towards ensuring such tragedies do not happen again,” she added.

Acute Encephalitis Syndrome and Japanese Encephalitis outbreaks are common in India, especially during the monsoon season, and claim hundreds of lives.

Often known as “brain fever,” encephalitis causes high fever, vomiting and, in severe cases, seizures, paralysis and coma. Infants and elderly people are particularly vulnerable.

Outbreaks of the virus tend to occur in poor, flood-hit areas such as Gorakhpur, where monsoons leave pools of stagnant water, allowing mosquitoes to breed and infect villagers.

Television pictures in mid-August — which showed parents holding the bodies of infants and saying they died because they did not have oxygen — led to widespread criticism of authorities in Uttar Pradesh state, where Gorakhpur is located.

The state, which is governed by Prime Minister Narendra Modi’s Bharatiya Janata Party, has fired the head of the hospital, as well as the head of the pediatrics department.

But the sacked hospital chief says he had repeatedly written to the administration to release funds to pay oxygen suppliers.

Government expenditure on public health is about one percent of GDP, among the world’s lowest. In recent years, Modi’s government has increased health spending and vowed to make healthcare more affordable.

But Chandra said Indians should help under-resourced hospitals provide basics like oxygen to prevent needless deaths.

“I seek support from other like-minded citizens to join hands to ensure that oxygen never runs out in our hospitals,” she said.

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